Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives
文献类型：期刊论文
| 作者 | Yuan Jing; Su Xin; Zhang Xin; Cong Lin; Guo Chun |
| 刊名 | CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
 |
| 出版日期 | 2011 |
| 卷号 | 27期号:6页码:955-957 |
| 关键词 | BIOLOGICAL-ACTIVITIES AGENTS 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-cquinoline-2-carboxamide derivative Cysteine protease inhibitor Antifungal activity |
| ISSN号 | 1005-9040 |
| 其他题名 | Design, Synthesis and Antifungal Activity of 6-Fluoro-3, 3a, 4, 5-tetrahydro-2H-pyrazolo 4, 3-c-quinoline-2-carboxamide Derivatives |
| 英文摘要 | A series of 6-fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-cquinoline-2-carboxamide derivatives was designed based on the bioisosterism and combination principle in drug design. The target compounds were synthesized from substituted aniline through Michael addition, cyclization, Mannich reaction and condensation with 4-substituted semicarbazides, and the structures were confirmed by mass spectrometry(MS) and H-1 NMR. The antifungal assay was carried out in vitro by two-fold dilution. The result shows that all the compounds are of antifungal activities, against the tested fungi at different levels. |
| 资助项目 | [National Science and Technology Major Projects of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4377190 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/152926]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Yuan Jing,Su Xin,Zhang Xin,et al. Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2011,27(6):955-957. |
| APA | Yuan Jing,Su Xin,Zhang Xin,Cong Lin,&Guo Chun.(2011).Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,27(6),955-957. |
| MLA | Yuan Jing,et al."Design, Synthesis and Antifungal Activity of 6-Fluoro-3,3a,4,5-tetrahydro-2H-pyrazolo4,3-c-quinoline-2-carboxamide Derivatives".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 27.6(2011):955-957. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。