Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate
文献类型：期刊论文
| 作者 | Jia H(贾辉)1; Zhong HY(钟涵宇)2; Zhang JY(张敬一)1 |
| 刊名 | 结构化学
 |
| 出版日期 | 2019 |
| 卷号 | 38.0期号:012页码:2070-2076 |
| 关键词 | cycolpropylamide analogues synthesis bioactivity microtubule-stabilizing agents |
| ISSN号 | 0254-5861 |
| 英文摘要 | Many small-molecule compounds were reported as microtubule-inhibitor with potential anticancer activities, such as combretastatin-A4(CA-4) analogue. The title compound which is one novel cyclopropylamide analogue of CA-4, namely as ethyl 1-((2-bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl)cyclopropanecarboxylate, has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 8.8002(6), b = 11.4525(8), c = 21.7870(16)A, β = 93.810(3)°, V = 2190.9(3)A^3, Z = 4, C22H23BrNO6, Mr = 477.32, Dc = 1.447 Mg/cm^3, F(000) = 980, λ(Cu Kα) = 1.54178A, μ = 2.883 mm^–1, R = 0.0691 and wR = 0.1958 for 6420 observed reflections(I > 2σ(I)). Importantly, the compound revealed potential anticancer activities in six cancer cells and could stimulate tubulin polymerization in vitro, indicating that the small-molecule could be selected as a lead compound for the development of microtubule stimulator. |
| 语种 | 中文 |
| CSCD记录号 | CSCD:6631701 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/153082]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Department of Pharmacy,First Affiliated Hospital Medical University |
| 推荐引用方式 GB/T 7714 | Jia H,Zhong HY,Zhang JY. Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate[J]. 结构化学,2019,38.0(012):2070-2076. |
| APA | 贾辉,钟涵宇,&张敬一.(2019).Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate.结构化学,38.0(012),2070-2076. |
| MLA | 贾辉,et al."Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate".结构化学 38.0.012(2019):2070-2076. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。