Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy
文献类型：期刊论文
| 作者 | Shi Kai3; Haynes Matthew3; Huang Leaf3 |
| 刊名 | FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:4页码:676-684 |
| 关键词 | ANTITUMOR IMMUNE-RESPONSES T-CELL RESPONSES CALCIUM-PHOSPHATE NANOPARTICLES IN-VIVO INDOLEAMINE 2,3-DIOXYGENASE DENDRITIC CELLS REGULATORY T ANTIGEN PRESENTATION DNA VACCINE IMMUNOSUPPRESSIVE NETWORKS vaccine nanoparticle tumor immunotherapy microenvironment |
| ISSN号 | 2095-0179 |
| 其他题名 | Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy |
| 英文摘要 | Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitopeassociated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems in vitro and in vivo, an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success. |
| 资助项目 | [NIH] ; [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6114002 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/153297]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.University North Carolina Chapel Hill, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA 3.University North Carolina Chapel Hill, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA |
| 推荐引用方式 GB/T 7714 | Shi Kai,Haynes Matthew,Huang Leaf. Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2017,11(4):676-684. |
| APA | Shi Kai,Haynes Matthew,&Huang Leaf.(2017).Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,11(4),676-684. |
| MLA | Shi Kai,et al."Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 11.4(2017):676-684. |
入库方式： OAI收割
来源：金属研究所
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