Design, Synthesis and Fungicidal Activity against Rhizoctonia solani of New Phenylpyrazoloxyl Propionic Acid Derivatives
文献类型：期刊论文
| 作者 | Yu Fuqiang; Guan Aiying; Sun Xufeng; Li Huichao; Li Xiaowu |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2019 |
| 卷号 | 39期号:2页码:397-405 |
| 关键词 | phenylpyrazoloxyl propionic acid derivatives intermediate derivatization method fungicidal activity Rhizoctonia solani structure-activity relationship |
| ISSN号 | 0253-2786 |
| 其他题名 | Design, Synthesis and Fungicidal Activity against Rhizoctonia solani of New Phenylpyrazoloxyl Propionic Acid Derivatives |
| 英文摘要 | Rice sheath blight disease, one of three most important diseases in rice, can lead to crop production loss seriously. However, the application of fungicides is an effective way to prevent rice from diseases. After being used for a period of time, the plant pathogenic fungi may develop resistance to chemical fungicide, so it is necessary to discover compounds with novel structures and further to address the problem of fungicide resistance. By employing the intermediate derivatisation method (IDM), twenty-five new phenylpyrazoloxyl propionic acid derivatives were designed and synthesized. The biological activities of title compounds were tested against Rhizoctonia solani and their structure-activity relationships (SAR) were discussed as well. The preliminary bioassay results displayed that some compounds exhibited an excellent fungicidal activity against Rhizoctonia solani, especially 24(1-(4-chlorophenyl)-1H-pyrazol-3-yl)oxy)-N-(4-nitrophenyl)propanamide ( 17 ) (EC50 =1.05 mg/L) and 24(1-(4-chlorophenyl)-1H-pyrazol-3-ypoxy)-N-(pyridin-2-yl)propanamide (22) (EC50 =1.02 mg/L) showing a comparable activity to the commercial contrast tebuconazole (EC50 =1.02 mg/L), and 24(1-(4-chlorophenyl)-1H-pyrazol-3-yl)oxy)-N-(3,4-dichlorophenyl)propanamide (20) (EC50 =0.95 mg/L) is a little more active than tebuconazole (EC50 =1.02 mg/L). |
| 资助项目 | [Liaoning Provincal Science and Technology Plan Projects] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6442607 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/153458]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Yu Fuqiang,Guan Aiying,Sun Xufeng,et al. Design, Synthesis and Fungicidal Activity against Rhizoctonia solani of New Phenylpyrazoloxyl Propionic Acid Derivatives[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2019,39(2):397-405. |
| APA | Yu Fuqiang,Guan Aiying,Sun Xufeng,Li Huichao,&Li Xiaowu.(2019).Design, Synthesis and Fungicidal Activity against Rhizoctonia solani of New Phenylpyrazoloxyl Propionic Acid Derivatives.CHINESE JOURNAL OF ORGANIC CHEMISTRY,39(2),397-405. |
| MLA | Yu Fuqiang,et al."Design, Synthesis and Fungicidal Activity against Rhizoctonia solani of New Phenylpyrazoloxyl Propionic Acid Derivatives".CHINESE JOURNAL OF ORGANIC CHEMISTRY 39.2(2019):397-405. |
入库方式： OAI收割
来源：金属研究所
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