Study of spatial signal transduction in bistable switches
文献类型：期刊论文
| 作者 | Zhao Qi5; Yao ChengGui3; Tang Jun2; Liu LiWei1 |
| 刊名 | FRONTIERS OF PHYSICS
 |
| 出版日期 | 2016 |
| 卷号 | 11期号:5 |
| 关键词 | PROTEIN-KINASE CASCADES POSITIVE-FEEDBACK NEGATIVE FEEDBACK CELL POLARITY BISTABILITY GRADIENTS ULTRASENSITIVITY OSCILLATIONS ACTIVATION OOCYTES signal processing reaction-diffusion model nonlinear dynamics spatial switch |
| ISSN号 | 2095-0462 |
| 其他题名 | Study of spatial signal transduction in bistable switches |
| 英文摘要 | Bistable switch modules are among the most important fundamental motifs in signal-transduction pathways. To better understand their spatial signal transduction, we model the diffusion process in the one-dimensional (1-D) domain. We find that when none of the elements diffuse, the response of the system exhibits a spatial switch-like property. However, when one of the elements is highly diffusible, the response of the system does not show any spatial switching behavior. Furthermore, we observe that the spatial responses of the system are more sensitive to the time constant of the switch when none of the elements are diffusible. Further, a slow loop keeps the system in the high steady state more positions than that in the fast loop. Finally, we consolidate our numerical results analytically by performing a mathematical method. |
| 资助项目 | [National Natural Science Foundation of China] ; [Education Department of Liaoning Province] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5881345 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/153746]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.大连交通大学 2.China University Min & Technol, Coll Sci, Xuzhou 221008, Peoples R China 3.绍兴文理学院 4.中国科学院金属研究所 5.辽宁大学 |
| 推荐引用方式 GB/T 7714 | Zhao Qi,Yao ChengGui,Tang Jun,et al. Study of spatial signal transduction in bistable switches[J]. FRONTIERS OF PHYSICS,2016,11(5). |
| APA | Zhao Qi,Yao ChengGui,Tang Jun,&Liu LiWei.(2016).Study of spatial signal transduction in bistable switches.FRONTIERS OF PHYSICS,11(5). |
| MLA | Zhao Qi,et al."Study of spatial signal transduction in bistable switches".FRONTIERS OF PHYSICS 11.5(2016). |
入库方式： OAI收割
来源：金属研究所
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