A new and efficient method for the synthesis of rocuronium bromide
文献类型：期刊论文
| 作者 | Wu XueYing2; Wang YaoLing1; Hai Li1; Gong Ping2; Wu Yong1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2017 |
| 卷号 | 28期号:2页码:487-492 |
| 关键词 | ULIPRISTAL ACETATE DERIVATIVES RECEPTORS THIAZOLE PYRAN HL-60 Rocuronium bromide 2 alpha,3 alpha-Epoxy steroid derivative NMBAs Fe-mediated New route |
| ISSN号 | 1001-8417 |
| 其他题名 | A new and efficient method for the synthesis of rocuronium bromide |
| 英文摘要 | Rocuronium bromide has been used as an aminosteroid non-depolarizing neuromuscular blocker and muscle relaxant. In this work, a new and efficient route for preparing a key intermediate 2 beta-(4morpholiny1)-16 beta-(1-pyrrolidiny1)-5 alpha-androstan-3 alpha,17 beta-diol (6) was developed through a ring-opening of epoxide followed by introducing and pyrrolidine. Compound 6 can easily provide rocuronium bromide and the overall yield of compound 6 in 5 steps increased to 57.8%, which was higher than currently reported methods. Extraordinarily, this method would avoid the generation of disubstituted impurities E and F which are difficult to remove. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved. |
| 资助项目 | [National Natural Science Foundation] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5934409 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/153901]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.四川大学 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Wu XueYing,Wang YaoLing,Hai Li,et al. A new and efficient method for the synthesis of rocuronium bromide[J]. CHINESE CHEMICAL LETTERS,2017,28(2):487-492. |
| APA | Wu XueYing,Wang YaoLing,Hai Li,Gong Ping,&Wu Yong.(2017).A new and efficient method for the synthesis of rocuronium bromide.CHINESE CHEMICAL LETTERS,28(2),487-492. |
| MLA | Wu XueYing,et al."A new and efficient method for the synthesis of rocuronium bromide".CHINESE CHEMICAL LETTERS 28.2(2017):487-492. |
入库方式： OAI收割
来源：金属研究所
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