Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese
文献类型：期刊论文
| 作者 | Zhao Jiuhan2; Wang Xiaohong2; Xu Jialiang2; Li Nan1; Shang Xiuli2; He Zhiyi2; Yang Jun2 |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2012 |
| 卷号 | 44期号:12页码:1023-1030 |
| ISSN号 | 1672-9145 |
| 关键词 | 5-LIPOXYGENASE ACTIVATING PROTEIN CAROTID-ARTERY ATHEROSCLEROSIS ISCHEMIC-STROKE PHOSPHODIESTERASE 4D MYOCARDIAL-INFARCTION CEREBRAL INFARCTION ALOX5AP GENE PDE4D GENE POPULATION RISK inflammation polymorphism atherothrombotic stroke ALOX5AP PDE4D |
| 其他题名 | Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese |
| 英文摘要 | Atherosclerosis is an important pathophysiological basis of atherothrombotic stroke (ATS), and inflammation plays a significant role in atherosclerosis formation. In this study, single-nucleotide polymorphisms (SNPs) in three key inflammation-related genes, 5-lipoxygenase activating protein (ALOX5AP), phosphodiesterase 4D (PDE4D), and interleukin-1 (IL-1), were investigated to determine their association with ATS in Northern Han Chinese. Six-hundred and eighty-two ATS patients and 598 unrelated controls were recruited. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism and matrix-assisted laser desorption ionization time-of-flight mass spectrometry primer extension. The genotype and allele frequencies of each SNP were statistically analyzed. Risk of ATS was found for the ALOX5AP SG13S114A/T AA genotype (P 0.040) and A allele (P 0.033), PDE4D SNP83C/T TT genotype (P 0.010) and T allele (P 0.008) and SNP219A/G GG genotype (P 0.025) and G allele (P 0.022), and the IL-1-889C/T T allele (P 0.035). The differences still remained significant after adjustment. The ALOX5AP HapA haplotype was not correlated with ATS (P 0.834), but GCGA represented an at-risk haplotype (P 0.008). Furthermore, the PDE4D AA haplotype at SNP219-220 might be an at-risk haplotype (P 0.013), while GA might be a protective haplotype (P 0.005). The ALOX5AP (SG13S114A/T), PDE4D (SNP83C/T, 219A/G), and IL-1 (-889C/T) SNPs were associated with an increased risk of ATS in Northern Han Chinese. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4708879 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/154236]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Jinzhou Cent Hosp, Department Neurol, Jinzhou 121000, Peoples R China 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhao Jiuhan,Wang Xiaohong,Xu Jialiang,et al. Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2012,44(12):1023-1030. |
| APA | Zhao Jiuhan.,Wang Xiaohong.,Xu Jialiang.,Li Nan.,Shang Xiuli.,...&Yang Jun.(2012).Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,44(12),1023-1030. |
| MLA | Zhao Jiuhan,et al."Association of inflammatory response gene polymorphism with atherothrombotic stroke in Northern Han Chinese".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 44.12(2012):1023-1030. |
入库方式： OAI收割
来源：金属研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。