Comparative evaluation of the effects of 5-Aza-2'-deoxycytidine and Trichostatin A on reactivation of hMLH1 in COC1/DDP ovarian cancer cell line
文献类型：期刊论文
| 作者 | Meng Chunfeng; Dai Dongqiu; Guo Kejun |
| 刊名 | CHINESE JOURNAL OF CANCER RESEARCH
 |
| 出版日期 | 2009 |
| 卷号 | 21期号:2页码:102-108 |
| 关键词 | DNA MISMATCH REPAIR METHYLATION GENE TRANSCRIPTION EXPRESSION PROMOTER RESISTANCE BINDING DEMETHYLATION REEXPRESSION Ovarian cancer DNA methylation Drug resistance hMLH1 5-Aza-2 '-deoxycytidine Trichostatin A |
| ISSN号 | 1000-9604 |
| 其他题名 | Comparative Evaluation of the Effects of 5-Aza-2'-deoxycytidine and Trichostatin A on Reactivation of hMLH1 in COC1/DDP Ovarian Cancer Cell Line |
| 英文摘要 | hMLH1 protein serves to detect the DNA damage caused by cisplatin (DDP) and destroys the cell. The absence of hMLH1 expression has been correlated with acquired resistance of ovarian cancer cells to platinum. The aim of this study was to determine the possible role of DNA methylation and histone H3 lysine 9 (H3-K9) acetylation on the loss of hMLH1 expression, and to evaluate the reversal effects of 5-Aza-2'-deoxycytidine (5-Aza-dC) and Trichostatin A (TSA) on DDP-resistance in ovarian cancer cell lines. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3525455 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/154451]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Meng Chunfeng,Dai Dongqiu,Guo Kejun. Comparative evaluation of the effects of 5-Aza-2'-deoxycytidine and Trichostatin A on reactivation of hMLH1 in COC1/DDP ovarian cancer cell line[J]. CHINESE JOURNAL OF CANCER RESEARCH,2009,21(2):102-108. |
| APA | Meng Chunfeng,Dai Dongqiu,&Guo Kejun.(2009).Comparative evaluation of the effects of 5-Aza-2'-deoxycytidine and Trichostatin A on reactivation of hMLH1 in COC1/DDP ovarian cancer cell line.CHINESE JOURNAL OF CANCER RESEARCH,21(2),102-108. |
| MLA | Meng Chunfeng,et al."Comparative evaluation of the effects of 5-Aza-2'-deoxycytidine and Trichostatin A on reactivation of hMLH1 in COC1/DDP ovarian cancer cell line".CHINESE JOURNAL OF CANCER RESEARCH 21.2(2009):102-108. |
入库方式： OAI收割
来源：金属研究所
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