Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment
文献类型：期刊论文
| 作者 | Chen Yu; Xiang Liangbi; Liu Jun; Zhou Dapeng; Yu Hailong; Wang Qi; Han Wenfeng; Ren Weijian |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:7页码:523-527 |
| ISSN号 | 1673-5374 |
| 关键词 | EVOKED-POTENTIALS INJURY NMDA MORPHINE MK-801 TRAUMA MOTOR RATS spinal cord injury dynorphin Kappa receptor N-methyl-D-aspartate receptor motor-evoked potential somatosensory-evoked potential electrophysiology |
| 其他题名 | Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment ☆ |
| 英文摘要 | The latencies of motor- and somatosensory-evoked potentials were prolonged to different degrees, and wave amplitude was obviously decreased, after injection of dynorphin into the rat subarachnoid cavity. The wave amplitude and latencies of motor- and somatosensory-evoked potentials were significantly recovered at 7 and 14 days after combined injection of dynorphin and either the kappa opioid receptor antagonist nor-binaltorphimine or the N-methyl-D-aspartate receptor antagonist MK-801. The wave amplitude and latency were similar in rats after combined injection of dynorphin and nor-binaltorphimine or MK-801. These results suggest that intrathecal injection of dynorphin causes damage to spinal cord function. Prevention of N-methyl-D-aspartate receptor or kappa receptor activation lessened the injury to spinal cord function induced by dynorphin. |
| 资助项目 | [Key Science and Technology Research and Development Program of Liaoning Province, China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4510578 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/154637]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Chen Yu,Xiang Liangbi,Liu Jun,et al. Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment[J]. NEURAL REGENERATION RESEARCH,2012,7(7):523-527. |
| APA | Chen Yu.,Xiang Liangbi.,Liu Jun.,Zhou Dapeng.,Yu Hailong.,...&Ren Weijian.(2012).Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment.NEURAL REGENERATION RESEARCH,7(7),523-527. |
| MLA | Chen Yu,et al."Kappa opioid receptor antagonist and N-methyl-D-aspartate receptor antagonist affect dynorphin-induced spinal cord electrophysiologic impairment".NEURAL REGENERATION RESEARCH 7.7(2012):523-527. |
入库方式： OAI收割
来源：金属研究所
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