Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5
文献类型：期刊论文
| 作者 | Li Xing Zhou2; Dai Xian Ping1; Lai Kang Ying1; Wang Li Li2; Zheng Zhi Bing2; Li Song2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2008 |
| 卷号 | 19期号:4页码:379-382 |
| 关键词 | BETA IDENTIFICATION KINASE activin-like kinases5 (ALK5) kinase inhibitors 1H-pyrazol-3(2H)-ones |
| ISSN号 | 1001-8417 |
| 其他题名 | Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2 H)-ones as inhibitors of ALK5 |
| 英文摘要 | A series of 2,4,5-triaryl substituted 1H-pyrazol-3(2H)-ones, as ALK5 inhibitors, were desigened, synthesized and evaluated in vitro. Most compounds exhibited noticeable ALK5 inhibition activities at 1 mu mol/L and displayed no significant cytotoxicities at 30 mu mol/L. (c) 2008 Song Li. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3316681 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/155599]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.Beijing Institute Pharmacol & Toxicol, Beijing 100850, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Xing Zhou,Dai Xian Ping,Lai Kang Ying,et al. Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5[J]. CHINESE CHEMICAL LETTERS,2008,19(4):379-382. |
| APA | Li Xing Zhou,Dai Xian Ping,Lai Kang Ying,Wang Li Li,Zheng Zhi Bing,&Li Song.(2008).Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5.CHINESE CHEMICAL LETTERS,19(4),379-382. |
| MLA | Li Xing Zhou,et al."Synthesis and biological evaluation of novel 2,4,5-triaryl-1 H-pyrazol-3(2H)-ones as inhibitors of ALK5".CHINESE CHEMICAL LETTERS 19.4(2008):379-382. |
入库方式： OAI收割
来源：金属研究所
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