Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration
文献类型：期刊论文
| 作者 | Xie, Bei; Chen, Mengting; Ding, Pinghui; Lei, Lei; Zhang, Xing; Zhu, Dan; Zou, Yujian; Deng, Zhili; Sun, Guoming; Li, Ji |
| 刊名 | APPLIED MATERIALS TODAY
 |
| 出版日期 | 2020-12-01 |
| 卷号 | 21 |
| DOI | 10.1016/j.apmt.2020.100805 |
| 英文摘要 | Current approaches fail at obtaining adequate functional human dermal papilla cells (DPCs) to regenerate hair follicles (HFs). Here we induce human dermal fibroblasts (hDFs) into hDPC-like cells (hDF-DPCs) through alginate-poly-L-lysine-alginate (APA) microencapsulation. Our results show that the derived hDF-DPCs are comparable to primary DPCs on the molecular level, and they can induce the formation of hair follicle-like structures and hair pigmentation in nude mice. RNA-seq analyses indicate the activation of Wnt signaling pathway during the hDF-DPCs conversion. Likewise, we demonstrate that mouse DFs differentiate into mouse DPC-like cells within the hydrogel microcapsules. The induction of dermal fibroblasts into DPC-like cells through biomimetic microencapsulation, devoid of chemical or gene reprogramming, would provide an alternative, abundant, and safe source of DPCs, which would help circumvent the bottleneck in DPC-based HF regeneration. (C) 2020 Elsevier Ltd. All rights reserved. |
| WOS记录号 | WOS:000599826000001 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/155652]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Xie, Bei,Chen, Mengting,Ding, Pinghui,et al. Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration[J]. APPLIED MATERIALS TODAY,2020,21. |
| APA | Xie, Bei.,Chen, Mengting.,Ding, Pinghui.,Lei, Lei.,Zhang, Xing.,...&Nie, Hemin.(2020).Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration.APPLIED MATERIALS TODAY,21. |
| MLA | Xie, Bei,et al."Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration".APPLIED MATERIALS TODAY 21(2020). |
入库方式： OAI收割
来源：金属研究所
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