Antibacterial activity of copper-bearing 316L stainless steel for the prevention of implant-related infection
文献类型：期刊论文
| 作者 | Zhuang, Yifu; Zhang, Shuyuan; Yang, Ke; Ren, Ling; Dai, Kerong |
| 刊名 | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
 |
| 出版日期 | 2020-02-01 |
| 卷号 | 108期号:2页码:484-495 |
| DOI | 10.1002/jbm.b.34405 |
| 英文摘要 | Implant-related infection (IRI) is a devastating complication in orthopedic procedures. Traditional materials used in orthopedics are susceptible to bacterial infection. In this study, we developed a copper-bearing 316L stainless steel (316L-Cu SS) for the prevention of IRI. This 316L-Cu SS allowed stable and continuous release of copper ions with a rate of 5.079 ng/cm(2)/day. Compared with 316L stainless steel (316L SS), 316L-Cu SS exhibited a broad-spectrum antibacterial effect against Staphylococcus aureus, Escherichia coli, and Staphylococcus epidermidis with the bacterial reduction percentages of 95.2, 94.8, and 94.1%, respectively. The antibiofilm activity was confirmed by crystal violet assay, scanning electron microscopy, and confocal laser scanning microscopy. The in vivo antibacterial performance was tested on a rat model. When nails were treated with a low concentration of bacteria, 316L SS group exhibit a bone infection with a radiographic score of 8.9 +/- 1.1 and a histological score of 10.4 +/- 1.0, which were higher than 316L-Cu SS group (1.2 +/- 0.2 and 0.9 +/- 0.2), indicating IRI was reduced by 316L-Cu SS. When nails were treated with a high concentration of bacteria, IRI was also alleviated by 316L-Cu SS. Together, these results demonstrated that 316L-Cu SS is a promising material for preventing IRI. |
| WOS记录号 | WOS:000505634000017 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/155722]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhuang, Yifu,Zhang, Shuyuan,Yang, Ke,et al. Antibacterial activity of copper-bearing 316L stainless steel for the prevention of implant-related infection[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,2020,108(2):484-495. |
| APA | Zhuang, Yifu,Zhang, Shuyuan,Yang, Ke,Ren, Ling,&Dai, Kerong.(2020).Antibacterial activity of copper-bearing 316L stainless steel for the prevention of implant-related infection.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS,108(2),484-495. |
| MLA | Zhuang, Yifu,et al."Antibacterial activity of copper-bearing 316L stainless steel for the prevention of implant-related infection".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS 108.2(2020):484-495. |
入库方式： OAI收割
来源：金属研究所
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