Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study
文献类型：期刊论文
| 作者 | Zhao Simin; Zhang Yuanyuan; Ju Ping; Gu Liqiang; Zhuang Rui; Zhao Longshan; Tang Xing; Bi Kaishun; Chen Xiaohui |
| 刊名 | Journal of Pharmaceutical Analysis
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:4页码:219-225 |
| 关键词 | 6258-70 HPLC–MS/MS Pharmacokinetics Tissue distribution Therapeutics. Pharmacology RM1-950 |
| ISSN号 | 2095-1779 |
| 其他题名 | Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study |
| 英文摘要 | Cancer is the leading cause of death all over the world. Among the chemotherapy drugs, taxanes play an important role in cancer treatment. 6258-70 is a new semi-synthetic taxane which has a broad spectrum of antitumor activity. A fast and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC–MS/MS) method was developed for quantification of 6258-70 in rat plasma and tissues in this paper. After extraction by liquid-liquid extraction method with methyl tert-butyl ether, the samples were separated on a Kinetex C18 column (50mm×2.1mm, 2.6μm, Phenomenex, USA) within 3min. The method was fully validated with the matrix effect between 87.7% and 99.5% and the recovery ranging from 80.3% to 90.1%. The intra- and inter-day precisions were less than 9.5% and the accuracy ranged from ?3.8% to 6.5%. The reliable method was successfully applied to the pharmacokinetics and tissue distribution studies of 6258-70 after intravenous administration in rats. The pharmacokinetic results indicated that the pharmacokinetic behavior of 6258-70 in rats was in accordance with linear features within tested dosage of 1 to 4mg/kg, and there was no significant difference between the two genders. The tissue distribution study showed that 6258-70 had an effective penetration, spread widely and rapidly and could cross blood-brain barrier. The results of pharmacokinetics and tissue distribution may provide a guide for future study. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:5777147 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/155810]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhao Simin,Zhang Yuanyuan,Ju Ping,et al. Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study[J]. Journal of Pharmaceutical Analysis,2016,6(4):219-225. |
| APA | Zhao Simin.,Zhang Yuanyuan.,Ju Ping.,Gu Liqiang.,Zhuang Rui.,...&Chen Xiaohui.(2016).Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study.Journal of Pharmaceutical Analysis,6(4),219-225. |
| MLA | Zhao Simin,et al."Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study".Journal of Pharmaceutical Analysis 6.4(2016):219-225. |
入库方式： OAI收割
来源：金属研究所
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