Growth of Dynamic Actin Filament via Brownian Dynamics Simulations
文献类型：期刊论文
| 作者 | Guo Kunkun2; Han Wenchi1 |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2011 |
| 卷号 | 69期号:2页码:145-152 |
| 关键词 | POLYMERIZATION KINETICS SYMMETRY-BREAKING MOTILITY DRIVEN CELL MOTILITY ADP-ACTIN MODEL TURNOVER brownian dynamics actin filament polymerization depolymerization |
| ISSN号 | 0567-7351 |
| 其他题名 | Growth of Dynamic Actin Filament via Brownian Dynamics Simulations |
| 英文摘要 | Actin polymerization is coupled with the hydrolysis of adenosine triphosphate (ATP). The hydrolysates of ATP are adenosine diphosphate (ADP) and inorganic phosphate (Pi). Therefore, each protomer within the actin filament can exhibit three different nucleotide states corresponding to bounded ATP, ADP/Pi and ADP molecules. These protomer states cause the filaments to form different spatial patterns, which will change various properties of the filament. The related model has been made to simulate the process of polymerization, depolymerization and hydrolysis via Brownian dynamics simulations, where the time evolution of depolymerization and hydrolysis is described as a continuous-time Markov process. In this paper, we focus on how to realize the chemical equilibrium between two ends of the filament, and study the growth behavior of long filaments as a function of ATP-actin monomer concentration. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4133426 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/156002]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.湖南大学 |
| 推荐引用方式 GB/T 7714 | Guo Kunkun,Han Wenchi. Growth of Dynamic Actin Filament via Brownian Dynamics Simulations[J]. ACTA CHIMICA SINICA,2011,69(2):145-152. |
| APA | Guo Kunkun,&Han Wenchi.(2011).Growth of Dynamic Actin Filament via Brownian Dynamics Simulations.ACTA CHIMICA SINICA,69(2),145-152. |
| MLA | Guo Kunkun,et al."Growth of Dynamic Actin Filament via Brownian Dynamics Simulations".ACTA CHIMICA SINICA 69.2(2011):145-152. |
入库方式： OAI收割
来源：金属研究所
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