Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes
文献类型：期刊论文
| 作者 | Wang Yan2; Zhao Fenghong2; Liao Yingjun1; Jin Yaping2; Sun Guifan2 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:31页码:2439-2445 |
| 关键词 | INTELLECTUAL FUNCTION NEURONAL-ACTIVITY DRINKING-WATER GLIAL-CELLS D-SERINE MODULATION RELEVANCE CHILDREN COMMUNICATION BANGLADESH arsenite astrocyte glutamate neuron cell viability intracellular free calcium gliotransmitter neurotoxicity neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes ☆ |
| 英文摘要 | The present study used cultures of primary astrocytes, isolated from neonatal rats, to verify the hypothesis that arsenite-induced neurotoxicity can influence neuronal function by altering glutamate-induced gliotransmitter release. Primary astrocytes were exposed to 0, 2.5, 5, 10, 20 or 30 mu M arsenite for 24 hours. Cell viability and morphological observations revealed that 5 mu M arsenic exposure could induce cytotoxicity. Cells were then cultured in the presence of 0, 2.5, 5, or 10 mu M arsenite for 24 hours and stimulated with 25 mu M glutamate for 10 minutes. Results showed that Ca2+(i) in astrocytes exposed to 5 and 10 mu M arsenite was significantly increased and levels of D-serine, y-aminobutyric acid and glycine in cultures exposed to 2.5-10 mu M arsenite were also increased. However, glutamate levels in the media were significantly increased only after treatment with 10 mu M arsenite. In conclusion, our findings suggest that arsenic exposure may affect glutamate-induced gliotransmitter release from astrocytes and further disturb neuronal function. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4694373 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/156050]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.华东师范大学 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Wang Yan,Zhao Fenghong,Liao Yingjun,et al. Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes[J]. NEURAL REGENERATION RESEARCH,2012,7(31):2439-2445. |
| APA | Wang Yan,Zhao Fenghong,Liao Yingjun,Jin Yaping,&Sun Guifan.(2012).Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes.NEURAL REGENERATION RESEARCH,7(31),2439-2445. |
| MLA | Wang Yan,et al."Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes".NEURAL REGENERATION RESEARCH 7.31(2012):2439-2445. |
入库方式： OAI收割
来源：金属研究所
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