中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes

文献类型:期刊论文

作者Wang Yan2; Zhao Fenghong2; Liao Yingjun1; Jin Yaping2; Sun Guifan2
刊名NEURAL REGENERATION RESEARCH
出版日期2012
卷号7期号:31页码:2439-2445
关键词INTELLECTUAL FUNCTION NEURONAL-ACTIVITY DRINKING-WATER GLIAL-CELLS D-SERINE MODULATION RELEVANCE CHILDREN COMMUNICATION BANGLADESH arsenite astrocyte glutamate neuron cell viability intracellular free calcium gliotransmitter neurotoxicity neural regeneration
ISSN号1673-5374
其他题名Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes ☆
英文摘要The present study used cultures of primary astrocytes, isolated from neonatal rats, to verify the hypothesis that arsenite-induced neurotoxicity can influence neuronal function by altering glutamate-induced gliotransmitter release. Primary astrocytes were exposed to 0, 2.5, 5, 10, 20 or 30 mu M arsenite for 24 hours. Cell viability and morphological observations revealed that 5 mu M arsenic exposure could induce cytotoxicity. Cells were then cultured in the presence of 0, 2.5, 5, or 10 mu M arsenite for 24 hours and stimulated with 25 mu M glutamate for 10 minutes. Results showed that Ca2+(i) in astrocytes exposed to 5 and 10 mu M arsenite was significantly increased and levels of D-serine, y-aminobutyric acid and glycine in cultures exposed to 2.5-10 mu M arsenite were also increased. However, glutamate levels in the media were significantly increased only after treatment with 10 mu M arsenite. In conclusion, our findings suggest that arsenic exposure may affect glutamate-induced gliotransmitter release from astrocytes and further disturb neuronal function.
资助项目[National Natural Science Foundation of China]
语种英语
CSCD记录号CSCD:4694373
源URL[http://ir.imr.ac.cn/handle/321006/156050]  
专题金属研究所_中国科学院金属研究所
作者单位1.华东师范大学
2.中国科学院金属研究所
推荐引用方式
GB/T 7714
Wang Yan,Zhao Fenghong,Liao Yingjun,et al. Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes[J]. NEURAL REGENERATION RESEARCH,2012,7(31):2439-2445.
APA Wang Yan,Zhao Fenghong,Liao Yingjun,Jin Yaping,&Sun Guifan.(2012).Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes.NEURAL REGENERATION RESEARCH,7(31),2439-2445.
MLA Wang Yan,et al."Arsenic exposure and glutamate-induced gliotransmitter release from astrocytes".NEURAL REGENERATION RESEARCH 7.31(2012):2439-2445.

入库方式: OAI收割

来源:金属研究所

浏览0
下载0
收藏0
其他版本

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。