Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10
文献类型：期刊论文
| 作者 | Guo Rong2; Huang Kui2; Jiang Tongzi2; Li Jian1; Li Yu2; Xing Xiaona2; Cao Yunpeng2 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:26页码:2005-2012 |
| 关键词 | ALZHEIMERS-DISEASE MOUSE MODEL FOLLOW-UP PEPTIDE NEUROPATHOLOGY A-BETA-1-40/42 VACCINATION IMMUNOGENS PATHOLOGY PROTEIN Alzheimer's disease immunotherapy gene vaccine amyloid plaque T cell immunity response neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10 |
| 英文摘要 | Immunotherapy for Alzheimer's disease (AD) is effective in improving cognitive function in transgenic mouse models of AD. Because the AN1792 beta-amyloid (A beta) 1-42 vaccine was halted because of T cell mediated meningoencephalitis, many scientists are searching for a novel vaccine to avoid the T cell mediated immune response caused by the Ar beta(1-42). Importantly, the time when the immunization is begun can influence the immune effect. In this study, an adenovirus vaccine was constructed containing 10 x A beta(3-10) repeats and gene adjuvant CpG DNA. Transgenic AD mice were immunized intranasally for 3 months. After 10 x A beta(3-10) vaccine immunization, high titers of anti-A beta(42) IgG1 predominant antibodies were induced. In spatial learning ability and probe tests, the 10 x A beta(3-10) immunized mice showed significantly improved memories compared to control mice. The 10 x A beta(3-10) vaccine resulted in a robust Th2 dominant humoral immune response and reduced learning deficits in AD mice. In addition, the 10 x A beta(3-10) vaccine might be more efficient if administered before A beta aggregation at an early stage in the AD mouse brain. Thus, the adenovirus vector encoding 10 x A beta(3-10) is a promising vaccine for AD. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4363505 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/156514]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Liaoning Med Coll, Affiliated Hosp 1, Department Neurol, Jinzhou 121001, Liaoning Provin, Peoples R China 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Guo Rong,Huang Kui,Jiang Tongzi,et al. Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10[J]. NEURAL REGENERATION RESEARCH,2011,6(26):2005-2012. |
| APA | Guo Rong.,Huang Kui.,Jiang Tongzi.,Li Jian.,Li Yu.,...&Cao Yunpeng.(2011).Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10.NEURAL REGENERATION RESEARCH,6(26),2005-2012. |
| MLA | Guo Rong,et al."Induced Th2 dominant immune response in APPswe, PSEN1dE9 transgenic mice after nasal immunization with an adenoviral vector encoding 10 tandem repeats of beta-amyloid 3-10".NEURAL REGENERATION RESEARCH 6.26(2011):2005-2012. |
入库方式： OAI收割
来源：金属研究所
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