Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
文献类型：期刊论文
| 作者 | Qin Haiming; Song Fulin; Han Hongguang; Qu Hong; Zhai Xingwen; Qin Bin; You Song |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:27页码:2105-2111 |
| 关键词 | ARTERY OCCLUSION WATER CHANNELS EXTRACT EGB-761 EDEMA NEUROPROTECTION PERMEABILITY ASTROCYTES PROTECTION MEMBRANE INJURY bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia |
| 英文摘要 | The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data suggest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins. |
| 资助项目 | [General Hospital of Shenyang Military Area Command of Chinese PLA] ; [Foundation of General Hospital of Shenyang Military Area Command of Chinese PLA] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4363518 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/156680]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Qin Haiming,Song Fulin,Han Hongguang,et al. Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia[J]. NEURAL REGENERATION RESEARCH,2011,6(27):2105-2111. |
| APA | Qin Haiming.,Song Fulin.,Han Hongguang.,Qu Hong.,Zhai Xingwen.,...&You Song.(2011).Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia.NEURAL REGENERATION RESEARCH,6(27),2105-2111. |
| MLA | Qin Haiming,et al."Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia".NEURAL REGENERATION RESEARCH 6.27(2011):2105-2111. |
入库方式： OAI收割
来源：金属研究所
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