Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
文献类型：期刊论文
| 作者 | Fu Li Qiang2; Guo Xing Sheng1; Liu Xin2; He Hui Li2; Wang Yu Ling1; Yang Yu She2 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 21期号:5页码:507-510 |
| 关键词 | PATHOGENS Synthesis Pleuromutilin C-2(S)-substituted Antimicrobial activity |
| ISSN号 | 1001-8417 |
| 其他题名 | Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives |
| 英文摘要 | In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity. a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for then in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. (C) 2010 Yu She Yang Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3892707 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/156712]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.中国科学院 |
| 推荐引用方式 GB/T 7714 | Fu Li Qiang,Guo Xing Sheng,Liu Xin,et al. Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(5):507-510. |
| APA | Fu Li Qiang,Guo Xing Sheng,Liu Xin,He Hui Li,Wang Yu Ling,&Yang Yu She.(2010).Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives.CHINESE CHEMICAL LETTERS,21(5),507-510. |
| MLA | Fu Li Qiang,et al."Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives".CHINESE CHEMICAL LETTERS 21.5(2010):507-510. |
入库方式： OAI收割
来源：金属研究所
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