Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine
文献类型：期刊论文
| 作者 | Wang Jun; Ge Jing; Yang Liu; Zhang Haiyan; Li Xuli; Xue Dan |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:28页码:2199-2205 |
| 关键词 | NMDA RECEPTOR PREECLAMPSIA HYPERHOMOCYSTEINEMIA HYPERTENSION PATHOPHYSIOLOGY MILD JUNCTIONS STRESS DEATH hyperhomocysteinemia homocysteine preeclampsia frontal cortex N-methyl-D-aspartate receptor nerve excitability cell apoptosis pregnancy brain neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine ☆ |
| 英文摘要 | Hyperhomocysteinemia is an important risk factor for preeclampsia-eclampsia. This study established a pregnant rat model of hyperhomocysteinemia, in which blood plasma homocysteine concentrations were twice or three times greater than that of normal pregnant rats. TUNEL revealed an increase in the number of apoptotic cells in the frontal cortex of pregnant rats with hyperhomocysteinemia. In addition, immunohistochemical staining detected activated nuclear factor-kB-positve cells in the frontal cortex. Reverse transcription-PCR detected that mRNA expression of the anti-apoptotic gene bcl-2 diminished in the frontal cortex. In situ hybridization and western blotting revealed that N-methyl-D-aspartate receptor 1 mRNA and protein expression was upregulated in the frontal cortex and hippocampus. These results indicate that hyperhomocysteinemia can induce brain cell apoptosis, increase nerve excitability, and promote the occurrence of preeclampsia in pregnant rats. |
| 资助项目 | [General Project of Medical Technology of Military] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4664136 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/157424]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Wang Jun,Ge Jing,Yang Liu,et al. Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine[J]. NEURAL REGENERATION RESEARCH,2012,7(28):2199-2205. |
| APA | Wang Jun,Ge Jing,Yang Liu,Zhang Haiyan,Li Xuli,&Xue Dan.(2012).Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine.NEURAL REGENERATION RESEARCH,7(28),2199-2205. |
| MLA | Wang Jun,et al."Brain cell apoptosis and enhancement of nervous excitability in pregnant rats with high plasma levels of homocysteine".NEURAL REGENERATION RESEARCH 7.28(2012):2199-2205. |
入库方式： OAI收割
来源：金属研究所
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