Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling
文献类型：期刊论文
| 作者 | Ma Yinghuan2; Bao Yongxin2; Li Chenghao2; Jiao Fubin1; Xin Hongjie2; Yuan Zhengwei2 |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2012 |
| 卷号 | 7期号:32页码:2485-2491 |
| 关键词 | NEURAL-TUBE DEFECTS PROGRAMMED CELL-DEATH EMBRYONIC-DEVELOPMENT INDUCED APOPTOSIS CASPASE 9 IN-VIVO ACTIVATION MECHANISMS PATHWAYS MICE retinoic acid neural tube defects myeloid tissues caspase-3 apoptotic kinase c-Jun N-terminal kinase mitogen-activated protein kinase neural development regeneration neural regeneration |
| ISSN号 | 1673-5374 |
| 其他题名 | Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling ★ |
| 英文摘要 | Fetal rat models with neural tube defects were established by injection with retinoic acid at 10 days after conception. The immunofiuorescence assay and western blot analysis showed that the number of caspase-3 positive cells in myeloid tissues for spina bifida manifesta was increased. There was also increased phosphorylation of c-Jun N-terminal kinase, a member of the mitogen activated protein kinase family. The c-Jun N-terminal kinase phosphorylation level was positively correlated with caspase-3 expression in myeloid tissues for spina bifida manifesta. Experimental findings indicate that abnormal apoptosis is involved in retinoic acid-induced dominant spina bifida formation in fetal rats, and may be associated with the c-Jun N-terminal kinase signal transduction pathway. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4694378 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/157512]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.Gen Advisor Off Chinese PLA, Bur Guard, Div Hlth, Beijing 100017, Peoples R China Bur Guard Div Hlth 2.中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Ma Yinghuan,Bao Yongxin,Li Chenghao,et al. Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling[J]. NEURAL REGENERATION RESEARCH,2012,7(32):2485-2491. |
| APA | Ma Yinghuan,Bao Yongxin,Li Chenghao,Jiao Fubin,Xin Hongjie,&Yuan Zhengwei.(2012).Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling.NEURAL REGENERATION RESEARCH,7(32),2485-2491. |
| MLA | Ma Yinghuan,et al."Correlation between spina bifida manifesta in fetal rats and c-Jun N-terminal kinase signaling".NEURAL REGENERATION RESEARCH 7.32(2012):2485-2491. |
入库方式： OAI收割
来源：金属研究所
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