Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety
文献类型：期刊论文
| 作者 | Zhang Bei; Zhao Yan Fang; Zhai Xin; Fan Wei Jie; Ren Jun Ling; Wu Chun Fu; Gong Ping |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2012 |
| 卷号 | 23期号:8页码:915-918 |
| 关键词 | RAF/MEK/ERK PATHWAY DUAL-ACTION INHIBITORS TARGETS SORAFENIB CANCER Diaryl ureas N-acylhydrazone Antiproliferative activities |
| ISSN号 | 1001-8417 |
| 其他题名 | Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety |
| 英文摘要 | A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line (HL-60), human lung adenocarcinoma epithelial cell line (A549) and human breast cancer cell line (MDA-MB-231) in vitro by standard MTT assay. The pharmacological results indicated that some compounds exhibited promising antitumor activities. Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC50 values of 0.13 mu mol/L, 0.7 mu mol/L and 0.5 mu mol/L, respectively. (C) 2012 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [National High Technology Research and Development Program ("863" Program) of China] ; [National Natural Science Foundation of China] ; [Shenyang Science and Technology Plan Projects] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4601190 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/157578]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhang Bei,Zhao Yan Fang,Zhai Xin,et al. Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety[J]. CHINESE CHEMICAL LETTERS,2012,23(8):915-918. |
| APA | Zhang Bei.,Zhao Yan Fang.,Zhai Xin.,Fan Wei Jie.,Ren Jun Ling.,...&Gong Ping.(2012).Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety.CHINESE CHEMICAL LETTERS,23(8),915-918. |
| MLA | Zhang Bei,et al."Design, synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone moiety".CHINESE CHEMICAL LETTERS 23.8(2012):915-918. |
入库方式： OAI收割
来源：金属研究所
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