Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design
文献类型：期刊论文
| 作者 | Gao Yang1; Tian Wen1; Han Xiaoxu1; Gao Feng2 |
| 刊名 | FRONTIERS OF MEDICINE
 |
| 出版日期 | 2017 |
| 卷号 | 11期号:4页码:480-489 |
| 关键词 | NEUTRALIZING ANTIBODY-RESPONSE RAPID DISEASE PROGRESSION INTRAVENOUS-DRUG-USERS HIV-1 DUAL INFECTION FEMALE SEX WORKERS T-CELL RESPONSES ANTIRETROVIRAL THERAPY AMSTERDAM COHORT HOMOSEXUAL-MEN HIGH-RISK human immunodeficiency virus type I superinfection incidence immune response |
| ISSN号 | 2095-0217 |
| 其他题名 | Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design |
| 英文摘要 | Superinfection is frequently detected among individuals infected by human immunodeficiency virus type I (HIV-1). Superinfection occurs at similar frequencies at acute and chronic infection stages but less frequently than primary infection. This observation indicates that the immune responses elicited by natural HIV-1 infection may play a role in curb of superinfection; however, these responses are not sufficiently strong to completely prevent superinfection. Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses than those elicited by primary infection. On the other hand, potent and broad neutralization responses are more often detected after superinfection than during monoinfection. This suggests that broadly neutralizing antibodies are more likely induced by sequential immunization of multiple different immunogens than with only one form of envelope glycoprotein immunogens. Understanding why the protection from superinfection by immunity induced by primary infection is insufficient and if superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine design. |
| 资助项目 | [National Natural Science Foundation of China] ; [Program for JLU Science and Technology Innovative Research Team] ; [NIAID of NIH] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:6141297 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/157942]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.吉林大学 3.杜克大学 |
| 推荐引用方式 GB/T 7714 | Gao Yang,Tian Wen,Han Xiaoxu,et al. Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design[J]. FRONTIERS OF MEDICINE,2017,11(4):480-489. |
| APA | Gao Yang,Tian Wen,Han Xiaoxu,&Gao Feng.(2017).Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design.FRONTIERS OF MEDICINE,11(4),480-489. |
| MLA | Gao Yang,et al."Immunological and virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine design".FRONTIERS OF MEDICINE 11.4(2017):480-489. |
入库方式： OAI收割
来源：金属研究所
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