Synthesis and in vitro antitumor activity of novel diaryl urea derivatives
文献类型：期刊论文
| 作者 | Zhao YanFang; Liu ZiJian; Zhai Xin; Ge DanDan; Huang Qiang; Gong Ping |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2013 |
| 卷号 | 24期号:5页码:386-388 |
| 关键词 | RECEPTOR TYROSINE KINASES INHIBITOR DISCOVERY SORAFENIB Diaryl ureas Synthesis Antitumor activity in vitro |
| ISSN号 | 1001-8417 |
| 其他题名 | Synthesis and in vitro antitumor activity of novel diaryl urea derivatives |
| 英文摘要 | A series of novel diaryl ureas containing 4-(2-amino-6-trifluromethyl)pyrimidine-4-ylpiperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC50 values of 0.016, 0.63, 0.001 mu mol/L, respectively. (C) 2013 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| 资助项目 | [National Natural Science Foundation of China] |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4846555 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/158027]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 中国科学院金属研究所 |
| 推荐引用方式 GB/T 7714 | Zhao YanFang,Liu ZiJian,Zhai Xin,et al. Synthesis and in vitro antitumor activity of novel diaryl urea derivatives[J]. CHINESE CHEMICAL LETTERS,2013,24(5):386-388. |
| APA | Zhao YanFang,Liu ZiJian,Zhai Xin,Ge DanDan,Huang Qiang,&Gong Ping.(2013).Synthesis and in vitro antitumor activity of novel diaryl urea derivatives.CHINESE CHEMICAL LETTERS,24(5),386-388. |
| MLA | Zhao YanFang,et al."Synthesis and in vitro antitumor activity of novel diaryl urea derivatives".CHINESE CHEMICAL LETTERS 24.5(2013):386-388. |
入库方式： OAI收割
来源：金属研究所
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