Expression of TRPC6 in benign and malignant human prostate tissues
文献类型：期刊论文
| 作者 | Yue Dan1; Wang Yong1; Xiao JianYing2; Wang Ping1; Ren ChangShan1 |
| 刊名 | ASIAN JOURNAL OF ANDROLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 11期号:5页码:541-547 |
| 关键词 | HEPATOCYTE GROWTH-FACTOR CANCER EPITHELIAL-CELLS PROGNOSTIC MARKER CHANNELS PROLIFERATION RECEPTOR TRPM8 PROGRESSION ENTRY TRPV6 benign prostatic hyperplasia immunohistochemistry prostate cancer TRPC6 |
| ISSN号 | 1008-682X |
| 其他题名 | Expression of TRPC6 in benign and malignant human prostate tissues |
| 英文摘要 | We investigated the expression of transient receptor potential canonical 6 (TRPC6) protein in benign and malignant human prostate tissues and in prostate cancer cell lines and the association with the stage, grade and androgen responsiveness of the tumors. Immunohistochemical techniques, Western blot and reverse transcription polymerase chain reaction (RT-PCR) were used to investigate TRPC6 expression. TRPC6 protein was detected in 9 of 20 (45.0%) of benign prostatic hyperplasia (BPH) cases, and there was a significant difference compared with prostate cancer (129 of 149 86.6%) (P < 0.01). TRPC6 expression was associated with the histological grade and extraprostatic extension (P < 0.01). Tumors of higher stage tended to have a higher frequency of TRPC6 protein staining, but the difference was not significant among T2, T3 and T4. TRPC6 expression difference between androgen-independent (AI) tumors and androgen-dependent (AD) tumors was not statistically significant. TRPC6 was also observed in prostate cancer cell lines. In summary, TRPC6 is detected in benign and malignant human prostate tissues and prostate cancer cell lines and is associated with the histological grade, Gleason score and extraprostatic extension of prostate cancer. |
| 语种 | 英语 |
| CSCD记录号 | CSCD:3679864 |
| 源URL | [http://ir.imr.ac.cn/handle/321006/158195]  |
| 专题 | 金属研究所_中国科学院金属研究所 |
| 作者单位 | 1.中国科学院金属研究所 2.中国科学院地质与地球物理研究所 |
| 推荐引用方式 GB/T 7714 | Yue Dan,Wang Yong,Xiao JianYing,et al. Expression of TRPC6 in benign and malignant human prostate tissues[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(5):541-547. |
| APA | Yue Dan,Wang Yong,Xiao JianYing,Wang Ping,&Ren ChangShan.(2009).Expression of TRPC6 in benign and malignant human prostate tissues.ASIAN JOURNAL OF ANDROLOGY,11(5),541-547. |
| MLA | Yue Dan,et al."Expression of TRPC6 in benign and malignant human prostate tissues".ASIAN JOURNAL OF ANDROLOGY 11.5(2009):541-547. |
入库方式： OAI收割
来源：金属研究所
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