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Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine

文献类型：期刊论文

作者Yuan, Xiaoxue2,3; Liu, Ran4; Zhang, Wenchang2,3; Song, Xiaoqiang2,3; Xu, Lei2; Zhao, Yan2; Shang, Lei1; Zhang, Jingsong2
刊名JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
出版日期2021-02-10
卷号63页码:210-215
ISSN号1005-0302
关键词Polyelectrolyte complex hydrogel Carboxymethyl chitosan Alginate Diffusion controlled release
DOI10.1016/j.jmst.2020.05.008
通讯作者Zhao, Yan(yanzhao@imr.ac.cn) ; Shang, Lei(shanglei6677@163.com) ; Zhang, Jingsong(jshzhang@imr.ac.cn)
英文摘要Controlled drug release technology is becoming a commercially sound methodology of administering pharmaceutical therapies, and it is important to predict and control the release kinetics to fully take advantage of this technology. Carboxylmethylchitosan (CMCS) and alginate (SA) blend membranes were successfully prepared by solution casting technique and exposing to acetic acid atmosphere, which induced the protonation of the amino groups of CMCS, and the formation of polyelectrolyte composite hydrogels. By using diclofenac diethylamine as the model drug, the diffusion controlled drug release behaviors of the membranes were studied based on permeation experiment, which indicated that the swelling rates of the membranes could be adjusted by simply changing the weight ratio of CMCS/SA and effectively changed the release rate of the membrane. The study shows that CMCS/SA blend membranes are promising biomaterials used for modulating the permeation behavior and developing advanced drug delivery systems. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目National Natural Science Foundation of China[U1608255]
WOS研究方向Materials Science ; Metallurgy & Metallurgical Engineering
语种英语
出版者JOURNAL MATER SCI TECHNOL
WOS记录号WOS:000608708100022
资助机构National Natural Science Foundation of China
源URL[http://ir.imr.ac.cn/handle/321006/159035]  
专题金属研究所_中国科学院金属研究所
通讯作者Zhao, Yan; Shang, Lei; Zhang, Jingsong
作者单位1.Shenyang Med Coll, Sch Pharm, Shenyang 110034, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
3.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China
4.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
推荐引用方式
GB/T 7714		 Yuan, Xiaoxue,Liu, Ran,Zhang, Wenchang,et al. Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2021,63:210-215.
APA Yuan, Xiaoxue.,Liu, Ran.,Zhang, Wenchang.,Song, Xiaoqiang.,Xu, Lei.,...&Zhang, Jingsong.(2021).Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,63,210-215.
MLA Yuan, Xiaoxue,et al."Preparation of carboxylmethylchitosan and alginate blend membrane for diffusion-controlled release of diclofenac diethylamine".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 63(2021):210-215.

入库方式： OAI收割

来源：金属研究所

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