Cynanchum hubeiense Wen. B. Xu, B.S. Xia & J.Y. Shen (Apocynaceae), a new species from Luotian County, Hubei Province, China, is described and illustrated. It is similar to C. callialatum Buch.-Ham. ex Wight, C. decipiens Schneid., C. brevipedunculatum J.Y.Shen and C. longipedunculatum M.G.Gilbert & P.T.Li, but differs from them by slightly angulate follicles, the shorter peduncle, corolla white to reddish, corolla lobes ovate, planar, stems without two leaflike stipules per node, and stems sparsely puberulent. Photographs, distribution, comparison with related species, and conservation assessment are provided for this rare vine species.