A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study
文献类型：期刊论文
| 作者 | Li, Zhengbang1; Qin, Sanan1; Li, Qizhai2,3 |
| 刊名 | STATISTICS IN MEDICINE
 |
| 出版日期 | 2021-05-10 |
| 卷号 | 40期号:10页码:2422-2434 |
| 关键词 | asymptotic distribution maximum minimum power Z‐ score |
| ISSN号 | 0277-6715 |
| DOI | 10.1002/sim.8912 |
| 英文摘要 | In this article, we propose a novel test via combining the maximum and minimum values among a large number of dependent Z-scores for testing the hypothesis with sparse signals. The proposed test employs the information about different signs of maximum and minimum Z-scores and thus power is gained. Its asymptotic null distribution is derived under the null hypothesis and some regular conditions. Extensive simulation studies are conducted to show the advantages of the proposed test by comparing with two existing ones. A real application to the lipids genome wide association study further shows its performances. |
| 资助项目 | Beijing Natural Science Foundation[Z180006] ; National Nature Science Foundation of China[11722113] ; Self-determined research funds of CCNU from the colleges' basic research of MOE[CCNU20TS002] |
| WOS研究方向 | Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics |
| 语种 | 英语 |
| WOS记录号 | WOS:000625327800001 |
| 出版者 | WILEY |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/58314]  |
| 专题 | 中国科学院数学与系统科学研究院 |
| 通讯作者 | Li, Qizhai |
| 作者单位 | 1.Cent China Normal Univ, Sch Math & Stat, Wuhan, Peoples R China 2.Chinese Acad Sci, Acad Math & Syst Sci, LSC, Zhongguancun East Rd,55, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Math Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Zhengbang,Qin, Sanan,Li, Qizhai. A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study[J]. STATISTICS IN MEDICINE,2021,40(10):2422-2434. |
| APA | Li, Zhengbang,Qin, Sanan,&Li, Qizhai.(2021).A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study.STATISTICS IN MEDICINE,40(10),2422-2434. |
| MLA | Li, Zhengbang,et al."A novel test by combining the maximum and minimum values among a large number of dependent Z-scores with application to genome wide association study".STATISTICS IN MEDICINE 40.10(2021):2422-2434. |
入库方式： OAI收割
来源：数学与系统科学研究院
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