Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus L. f. Ker-Gawl. as a case study
文献类型：期刊论文
| 作者 | Jin, Xu1,2; Zhang, Jianqing1; Li, Yun1; Wu, Wenyong1,2; Zhang, Hang1,2; Yao, Changliang1; Wei, Wenlong1; Yao, Shuai1; Huang, Yong1; Qu, Hua1 |
| 刊名 | JOURNAL OF SEPARATION SCIENCE
 |
| 出版日期 | 2021-04-01 |
| 卷号 | 44期号:7页码:1440-1451 |
| 关键词 | authentication multicriteria decision making nontargeted metabolomics quality markers traditional Chinese medicine |
| ISSN号 | 1615-9306 |
| DOI | 10.1002/jssc.202000655 |
| 通讯作者 | Guo, De-an(daguo@simai.ac.cn) |
| 英文摘要 | A key segment in medicinal plant authentication is the establishment of quality markers that embody the intrinsic metabolites difference independent of instruments and experiment conditions. A strategy integrating nontargeted metabolomics and multicriteria decision-making model for robust quality markers discovery is presented and applied to authenticate Ophiopogon japonicus (L. f.) Ker-Gawl. First, an ultra-performance liquid chromatography/quadrupole time-of-flight MSE approach was established for global metabolites profiling and identification. Second, multivariate statistical analysis was performed to explore potential quality markers of different origins of ophiopogonis radix. Third, potential quality markers were ordered and filtered by multicriteria decision-making model to infer robust quality markers and further validated in different instruments and experiment conditions by validation model. Fourth, the validation model using the robust quality markers managed to discriminate the origins of ophiopogonis radix samples procured from the herbal markets. Consequently, two robust quality markers, cixi-ophiopogon B and ophiopogonin D, were discovered and further validated on different instruments and experiment conditions. This integrated strategy provided a practical solution for reliable and convenient authentication of geo-au then tic herb. |
| 资助项目 | National Key R&D Program of China[2019YFC1711000] ; National Key R&D Program of China[2018YFC1707900] ; National Natural Science Foundation of China[81530095] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000637348700013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295217]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Guo, De-an |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Haike Rd 501, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jin, Xu,Zhang, Jianqing,Li, Yun,et al. Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus L. f. Ker-Gawl. as a case study[J]. JOURNAL OF SEPARATION SCIENCE,2021,44(7):1440-1451. |
| APA | Jin, Xu.,Zhang, Jianqing.,Li, Yun.,Wu, Wenyong.,Zhang, Hang.,...&Guo, De-an.(2021).Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus L. f. Ker-Gawl. as a case study.JOURNAL OF SEPARATION SCIENCE,44(7),1440-1451. |
| MLA | Jin, Xu,et al."Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus L. f. Ker-Gawl. as a case study".JOURNAL OF SEPARATION SCIENCE 44.7(2021):1440-1451. |
入库方式： OAI收割
来源：上海药物研究所
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