Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity
文献类型：期刊论文
| 作者 | Wang, Zhiwan1,2,3; Gong, Xiang1,2,3; Li, Jie1,2,3; Wang, Hong1,2,3; Xu, Xiaoxuan1,2,3; Li, Yaping1,2,3 ; Sha, Xianyi4; Zhang, Zhiwen1,2,3,5
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| 刊名 | ACS NANO
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| 出版日期 | 2021-03-23 |
| 卷号 | 15期号:3页码:5405-5419 |
| ISSN号 | 1936-0851 |
| 关键词 | polyfluorocarbon nanovehicle oxygen tumor hypoxia antitumor immunity |
| DOI | 10.1021/acsnano.1c00033 |
| 通讯作者 | Zhang, Zhiwen() |
| 英文摘要 | Hypoxia is a critical cause of tumor immunosuppression, and it significantly limits the efficacy of many anticancer modalities. Herein, we report an amphiphilic F-11-derivative-based oxygen-delivering polyfluorocarbon nanovehicle loading photodynamic DiIC(18)(5) and reactive oxygen species (ROS)-sensitive prodrug of chemo-immunomodulatory gemcitabine (PF(11)DG), aimed at relieving tumor hypoxia and boosting antitumor immunity for cancer therapy. We optimized F-11-based polyfluorocarbon nanovehicles with a 10-fold enhancement of tumor oxygenation. PF(11)DG exhibited intriguing capabilities, such as oxygen-dissolving, ROS production, and responsive drug release. In tumors, PF(11)DG exhibited flexible intratumoral permeation and boosted robust antitumor immune responses upon laser irradiation. Notably, the treatment of PF(11)DG plus laser irradiation (PF(11)DG +L) significantly retarded the tumor growth with an 82.96% inhibition in the 4T1 breast cancer model and a 93.6% inhibition in the PANC02 pancreatic cancer model with better therapeutic benefits than non-oxygen-delivering nanovehicles. Therefore, this study presents an encouraging polyfluorocarbon nanovehicle with deep tumor-penetrating and hypoxia-relieving capacity to boost antitumor immunity for cancer treatment. |
| 资助项目 | National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000634569100147 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295253]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Zhiwan,Gong, Xiang,Li, Jie,et al. Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity[J]. ACS NANO,2021,15(3):5405-5419. |
| APA | Wang, Zhiwan.,Gong, Xiang.,Li, Jie.,Wang, Hong.,Xu, Xiaoxuan.,...&Zhang, Zhiwen.(2021).Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity.ACS NANO,15(3),5405-5419. |
| MLA | Wang, Zhiwan,et al."Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity".ACS NANO 15.3(2021):5405-5419. |
入库方式： OAI收割
来源：上海药物研究所
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