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Rh-Catalyzed C-H alkylation enabling modular synthesis of CF3-substituted benzannulated macrocyclic inhibitors of B cell responses dagger

文献类型：期刊论文

作者Sun, Tao1,2; He, Shijun3,4; Xu, Zhongliang3; Zuo, Jianping3,4; Yu, Yang1,2; Yang, Weibo3,4,5
刊名ORGANIC & BIOMOLECULAR CHEMISTRY
出版日期2021-03-24
页码6
ISSN号1477-0520
DOI10.1039/d1ob00296a
通讯作者Yu, Yang(yangyu2017@shu.edu.cn) ; Yang, Weibo(yweibo@simm.ac.cn)
英文摘要Inspired by aspirin and chalcone, herein, we describe a modular biomimetic strategy to achieve a new class of CF3-bearing benzannulated macrolactams. The key to the success of macrolactams was the utilization of a highly chemoselective Rh(iii)-catalyzed native carboxylic acid-directed C-H alkylation. Moreover, the unique CF3-containing benzannulated macrocycles showed decent immunosuppressive effects on B cells in vitro, including proliferation, activation, and antibody production upon specific stimulation implicating TLR and BCR signaling.
资助项目NSFC[21702217] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Shanghai-Technology Innovation Action Plan[18JC1415300]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000637061400001
出版者ROYAL SOC CHEMISTRY
源URL[http://119.78.100.183/handle/2S10ELR8/295267]  
专题中国科学院上海药物研究所
通讯作者Yu, Yang; Yang, Weibo
作者单位1.Shanghai Univ, Ctr Supramol Chem & Catalysis, 99 Shang Da Rd, Shanghai 200444, Peoples R China
2.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Key Lab Receptor Res, Shanghai, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Tao,He, Shijun,Xu, Zhongliang,et al. Rh-Catalyzed C-H alkylation enabling modular synthesis of CF3-substituted benzannulated macrocyclic inhibitors of B cell responses dagger[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2021:6.
APA Sun, Tao,He, Shijun,Xu, Zhongliang,Zuo, Jianping,Yu, Yang,&Yang, Weibo.(2021).Rh-Catalyzed C-H alkylation enabling modular synthesis of CF3-substituted benzannulated macrocyclic inhibitors of B cell responses dagger.ORGANIC & BIOMOLECULAR CHEMISTRY,6.
MLA Sun, Tao,et al."Rh-Catalyzed C-H alkylation enabling modular synthesis of CF3-substituted benzannulated macrocyclic inhibitors of B cell responses dagger".ORGANIC & BIOMOLECULAR CHEMISTRY (2021):6.

入库方式： OAI收割

来源：上海药物研究所

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