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Identification of the absorbed ingredients and metabolites in rats after an intravenous administration of Tanreqing injection using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

文献类型：期刊论文

作者Xie, Like1,2; Wang, Yangyang2,3; Yin, Hao2,3; Li, Jiajia2,3; Xu, Zhou2,3; Sun, Zhaolin2,3; Liu, Fang2,3; Zhang, Xiaoli4; Liu, Shaoyong4; Sun, Jianguo1
刊名JOURNAL OF SEPARATION SCIENCE
出版日期2021-04-09
页码16
关键词COVID‐ 19 metabolic profiles quadrupole time‐ of‐ flight mass spectrometry Tanreqing injection traditional Chinese medicine
ISSN号1615-9306
DOI10.1002/jssc.202000898
通讯作者Sun, Jianguo(jgsun@cpu.edu.cn) ; Tian, Xiaoting(zhghydxtxt@163.com) ; Huang, Chenggang(cghsimm@126.com)
英文摘要The metabolic profiles of Tanreqing injection, which is a traditional Chinese medicine recommended for complementary administration to treat a novel coronavirus, have remained unclear, which inhibit the understanding of the effective chemical compounds of Tanreqing injection. In this study, a sensitive high-performance liquid chromatography quadrupole time-of-flight mass spectrometry method was used to identify the compounds and metabolites in various biosamples, including plasma, bile, liver, lung, kidney, urine, and feces, following the intravenous administration of Tanreqing injection in rats. A total of 89 compounds were characterized in the biosamples of Tanreqing injection-treated rats including 25 precursor constituents and 64 metabolites. Nine flavonoid compounds, twelve phenolic acids, and four iridoid glycosides were identified in the rats. Their metabolites were mainly produced by glucuronidation, deglucuronidation, glycosylation, deglycosylation, methylation, demethylation, N-heterocyclisation, sulphation, dehydroxylation, decarboxylation, dehydration, hydroxylation, and corresponding recombination reactions. This study was the first to comprehensively investigate the metabolic profile of Tanreqing injection and provides a scientific basis to further elucidate the pharmacodynamic material basis and therapeutic mechanism of Tanreqing injection.
资助项目National Science and Technology Major Project of the Ministry of Science andTechnology of China[2019ZX09201001-001-008] ; Shanghai Science andTechnologyDevelopment Funds[18401931300] ; Youth Innovation Promotion Association ofChineseAcademy of Sciences[2019280]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000638214100001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/295273]  
专题中国科学院上海药物研究所
通讯作者Sun, Jianguo; Tian, Xiaoting; Huang, Chenggang
作者单位1.China Pharmaceut Univ, Key Lab Drug Metab & Pharmacokinet, State Key Lab Nat Med, Nanjing, Jiangsu, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Shanghai Kaibao Pharmaceut Co Ltd, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Xie, Like,Wang, Yangyang,Yin, Hao,et al. Identification of the absorbed ingredients and metabolites in rats after an intravenous administration of Tanreqing injection using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry[J]. JOURNAL OF SEPARATION SCIENCE,2021:16.
APA Xie, Like.,Wang, Yangyang.,Yin, Hao.,Li, Jiajia.,Xu, Zhou.,...&Huang, Chenggang.(2021).Identification of the absorbed ingredients and metabolites in rats after an intravenous administration of Tanreqing injection using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.JOURNAL OF SEPARATION SCIENCE,16.
MLA Xie, Like,et al."Identification of the absorbed ingredients and metabolites in rats after an intravenous administration of Tanreqing injection using high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry".JOURNAL OF SEPARATION SCIENCE (2021):16.

入库方式： OAI收割

来源：上海药物研究所

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