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Dihydro-beta-agarofuran-Type Sesquiterpenoids from the Seeds of Celastrus virens and Their Multidrug Resistance Reversal Activity against the KB/VCR Cell Line

文献类型：期刊论文

作者Mu, Hongyan1,2; Tang, Shuai3,4,5; Zuo, Quan1,2; Huang, Min2,3,4; Zhao, Weimin1,2
刊名JOURNAL OF NATURAL PRODUCTS
出版日期2021-03-26
卷号84期号:3页码:588-600
ISSN号0163-3864
DOI10.1021/acs.jnatprod.0c01182
通讯作者Zhao, Weimin(wmzhao@simm.ac.cn)
英文摘要Twenty-nine dihydro-beta-agarofuran-type sesquiterpenoids, including 17 new and 12 known compounds, were obtained from the seeds of Celastrus virens. The structures of the new isolates were characterized by spectroscopic methods and X-ray diffraction analysis. Among these, 20 sesquiterpenoids were evaluated for their multidrug resistance (MDR) reversal activity against the KB/VCR cell line. As a result, compounds 6 and 8 were found to exhibit MDR-reversal activity of more than 10-fold at a concentration of 2 mu M, and the reversal fold (RF) ratios of compounds 19, 21, and 24 were >97.9 at a 20 mu M nontoxic concentration level.
资助项目National Key Research and Development Program of China[2019YFC1711300]
WOS研究方向Plant Sciences ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000635469000005
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/295291]  
专题新药研究国家重点实验室
通讯作者Zhao, Weimin
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
5.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
推荐引用方式
GB/T 7714		 Mu, Hongyan,Tang, Shuai,Zuo, Quan,et al. Dihydro-beta-agarofuran-Type Sesquiterpenoids from the Seeds of Celastrus virens and Their Multidrug Resistance Reversal Activity against the KB/VCR Cell Line[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(3):588-600.
APA Mu, Hongyan,Tang, Shuai,Zuo, Quan,Huang, Min,&Zhao, Weimin.(2021).Dihydro-beta-agarofuran-Type Sesquiterpenoids from the Seeds of Celastrus virens and Their Multidrug Resistance Reversal Activity against the KB/VCR Cell Line.JOURNAL OF NATURAL PRODUCTS,84(3),588-600.
MLA Mu, Hongyan,et al."Dihydro-beta-agarofuran-Type Sesquiterpenoids from the Seeds of Celastrus virens and Their Multidrug Resistance Reversal Activity against the KB/VCR Cell Line".JOURNAL OF NATURAL PRODUCTS 84.3(2021):588-600.

入库方式： OAI收割

来源：上海药物研究所

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