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Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy

文献类型：期刊论文

作者Zhu, Runqi1,2,3; Lang, Tianqun1,2,3,4; Yan, Wenlu1,2,3; Zhu, Xiao1,2,3; Huang, Xin1,2,3; Yin, Qi1,2,3,4; Li, Yaping1,2,3,4,5
刊名ADVANCED SCIENCE
出版日期2021-03-09
页码32
关键词cancer therapy carcinogenesis drug delivery system gut microbiota modulation
DOI10.1002/advs.202003542
通讯作者Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Gut microbiota have close interactions with the host. It can affect cancer progression and the outcomes of cancer therapy, including chemotherapy, immunotherapy, and radiotherapy. Therefore, approaches toward the modulation of gut microbiota will enhance cancer prevention and treatment. Modern drug delivery systems (DDS) are emerging as rational and promising tools for microbiota intervention. These delivery systems have compensated for the obstacles associated with traditional treatments. In this review, the essential roles of gut microbiota in carcinogenesis, cancer progression, and various cancer therapies are first introduced. Next, advances in DDS that are aimed at enhancing the efficacy of cancer therapy by modulating or engineering gut microbiota are highlighted. Finally, the challenges and opportunities associated with the application of DDS targeting gut microbiota for cancer prevention and treatment are briefly discussed.
WOS关键词FUSOBACTERIUM-NUCLEATUM ; COLON-CANCER ; HELICOBACTER-PYLORI ; COLORECTAL-CANCER ; HUMAN HEALTH ; MOUSE MODEL ; BUTYRATE ; INFLAMMATION ; DIVERSITY ; BACTERIA
资助项目National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[31930066] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Natural Science Foundation of Shanghai[19ZR1479900] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Key Scientific Research Program of CAS[QYZDJ-SSW-SMC020] ; International Partnership Program of CAS[153631KYSB20190013] ; SA-SIBS Scholarship Program
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:000626766400001
源URL[http://119.78.100.183/handle/2S10ELR8/295365]  
专题新药研究国家重点实验室
通讯作者Yin, Qi; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
4.Yantai Key Lab Nanomed & Adv Preparat, Yantai Inst Mat Med, Yantai 264000, Peoples R China
5.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Runqi,Lang, Tianqun,Yan, Wenlu,et al. Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy[J]. ADVANCED SCIENCE,2021:32.
APA Zhu, Runqi.,Lang, Tianqun.,Yan, Wenlu.,Zhu, Xiao.,Huang, Xin.,...&Li, Yaping.(2021).Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.ADVANCED SCIENCE,32.
MLA Zhu, Runqi,et al."Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy".ADVANCED SCIENCE (2021):32.

入库方式： OAI收割

来源：上海药物研究所

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