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Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry

文献类型：期刊论文

作者Li, Yufen1; Li, Songwei1,2; Cuadrado, Cristina3; Gao, Chenglong4; Wu, Qihao1; Li, Xiaolu1; Pang, Tao4; Daranas, Antonio Hernandez3; Guo, Yuewei1; Li, Xuwen1
刊名CHINESE CHEMICAL LETTERS
出版日期2021
卷号32期号:1页码:271-276
关键词Soft coral Sarcophyton tortuosum Biscembranoid Stereochemistry Anti-inflammatory
ISSN号1001-8417
DOI10.1016/j.cclet.2020.11.037
通讯作者Daranas, Antonio Hernandez(adaranas@ull.edu.es) ; Guo, Yuewei(ywguo@simm.ac.cn) ; Li, Xuwen(xwli@simm.ac.cn)
英文摘要Five novel biscembranoids, ximaolides H-L (1-5), along with four known related compounds (6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of the new compounds were determined by extensive spectroscopic analysis, quantum chemical calculations, and/or by comparing their CD spectra with those of the known compounds. Compounds 1 and 2 are the first examples of biscembranoids bearing a 1,35-bridged lactone moiety, 4 is the first biscembranoid comprising an uncommon oxetane ring, and 5 represents the first 36-peroxyl biscembranoid. Ximaolides I (2), K (4) and F (9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-alpha protein release in RAW264.7 macrophages. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[8202290170] ; National Natural Science Foundation of China (NSFC)[42076099] ; NSFC/CNRS (Centre National de la Recherche Scientifique) Joint Project[81811530284] ; National Key Research and Development Program of China[2018YFC0310903] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Shanghai Rising-Star Program[20QA1411100]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000618541800048
出版者ELSEVIER SCIENCE INC
源URL[http://119.78.100.183/handle/2S10ELR8/295556]  
专题新药研究国家重点实验室
通讯作者Daranas, Antonio Hernandez; Guo, Yuewei; Li, Xuwen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Inst Prod Nat & Agrobiol, Consejo Super Invest Cient IPNA CSIC, San Cristobal la Laguna 38206, Spain
4.China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, State Key Lab Nat Med, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Peoples R China
推荐引用方式
GB/T 7714		 Li, Yufen,Li, Songwei,Cuadrado, Cristina,et al. Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry[J]. CHINESE CHEMICAL LETTERS,2021,32(1):271-276.
APA Li, Yufen.,Li, Songwei.,Cuadrado, Cristina.,Gao, Chenglong.,Wu, Qihao.,...&Li, Xuwen.(2021).Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry.CHINESE CHEMICAL LETTERS,32(1),271-276.
MLA Li, Yufen,et al."Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry".CHINESE CHEMICAL LETTERS 32.1(2021):271-276.

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来源：上海药物研究所

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