Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination
文献类型：期刊论文
| 作者 | Wang, Mei-Ling1; Xu, Hui2; Li, Han-Yuan2; Ma, Biao2; Wang, Zhen-Yu3; Wang, Xing2; Dai, Hui-Xiong2,4
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2021-03-19 |
| 卷号 | 23期号:6页码:2147-2152 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.1c00296 |
| 通讯作者 | Dai, Hui-Xiong(hxdai@simm.ac.cn) |
| 英文摘要 | Mizoroki-Heck reaction of unstrained aryl ketone with acrylate/styrene is accomplished via palladium-catalyzed ligand-promoted C-C bond cleavage. Various (hetero)aryl ketones are compatible in the reaction, affording the alkene product in good to excellent yields. Further applications in the late-stage olefination of some drugs, natural products, and fragrance-derived aryl ketones demonstrate the synthetic utility of this protocol. By employing ketone as both the directing group and the leaving group, 1,2-bifunctionalization is achieved via sequential ortho-C-H alkylation/ipso-Heck olefination. |
| 资助项目 | Shanghai Institute of Materia Medica ; Chinese Academy of Sciences ; National Natural Science Foundation of China[21772211] ; National Natural Science Foundation of China[21920102003] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Science and Technology Commission of Shanghai Municipality[18431907100] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000631439700036 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295565]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Dai, Hui-Xiong |
| 作者单位 | 1.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China 2.Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Jiangsu, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Mei-Ling,Xu, Hui,Li, Han-Yuan,et al. Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination[J]. ORGANIC LETTERS,2021,23(6):2147-2152. |
| APA | Wang, Mei-Ling.,Xu, Hui.,Li, Han-Yuan.,Ma, Biao.,Wang, Zhen-Yu.,...&Dai, Hui-Xiong.(2021).Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination.ORGANIC LETTERS,23(6),2147-2152. |
| MLA | Wang, Mei-Ling,et al."Mizoroki-Heck Reaction of Unstrained Aryl Ketones via Ligand-Promoted C-C Bond Olefination".ORGANIC LETTERS 23.6(2021):2147-2152. |
入库方式： OAI收割
来源：上海药物研究所
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