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Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry

文献类型：期刊论文

作者Sun, Li-Li1,2; Li, Wang-Sheng1,3; Li, Jie1,4; Zhang, Hai-Yan1,5; Yao, Li-Gong1; Luo, Hui3; Guo, Yue-Wei1,2; Li, Xu-Wen1,2
刊名JOURNAL OF ORGANIC CHEMISTRY
出版日期2021-02-19
卷号86期号:4页码:3367-3376
ISSN号0022-3263
DOI10.1021/acs.joc.0c02742
通讯作者Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要The chemical investigation of the South China Sea soft coral Sinularia humilis has resulted in the isolation of a library of diverse diterpenoids, including four new cembranoids, namely, humilisins A-D (1-4), two new uncommon diterpenoids possessing a tetradecahydrocyclopenta [3',4'] cyclobuta [1',2':4,5] cyclonona [1,2- b]-oxirene ring system, namely, humilisins E and F (5 and 6), and eight known related compounds (7-14). Humilisin A (1) is the first cembranoid with an ether linkage between C-3 and C-7. The structures and absolute configurations of 1-8 were determined by extensive spectroscopic data analyses, chemical reactions, and a series of quantum chemical calculations including quantum mechanical-nuclear magnetic resonance (QM-NMR), time-dependent density functional theory-electronic circular dichroism (TDDFT-ECD), and optical rotatory dispersion (ORD) methods. In bioassay, compound 6 displayed anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated BV-2 microglia cells.
资助项目Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[82022069] ; Natural Science Foundation of China[42076099] ; Shanghai Rising-Star Program[20QA1411100] ; National Key Research and Development Program of China[2018YFC0310903] ; SKLDR/SIMM Project[SIMM1903ZZ-04]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000621599900021
源URL[http://119.78.100.183/handle/2S10ELR8/295614]  
专题新药研究国家重点实验室
通讯作者Guo, Yue-Wei; Li, Xu-Wen
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Guangdong Med Univ, Marine Biomed Res Inst, Key Lab Zhanjiang R&D Marine Microbial Resources, Zhanjiang 524023, Peoples R China
4.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China
5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Li-Li,Li, Wang-Sheng,Li, Jie,et al. Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry[J]. JOURNAL OF ORGANIC CHEMISTRY,2021,86(4):3367-3376.
APA Sun, Li-Li.,Li, Wang-Sheng.,Li, Jie.,Zhang, Hai-Yan.,Yao, Li-Gong.,...&Li, Xu-Wen.(2021).Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry.JOURNAL OF ORGANIC CHEMISTRY,86(4),3367-3376.
MLA Sun, Li-Li,et al."Uncommon Diterpenoids from the South China Sea Soft Coral Sinularia humilis and Their Stereochemistry".JOURNAL OF ORGANIC CHEMISTRY 86.4(2021):3367-3376.

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来源：上海药物研究所

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