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Engineering Oxaliplatin Prodrug Nanoparticles for Second Near-Infrared Fluorescence Imaging-Guided Immunotherapy of Colorectal Cancer

文献类型：期刊论文

作者Zhu, Qiurong2,3,4; Sun, Fang3,4; Li, Tianliang3,4; Zhou, Mengxue3,4; Ye, Jiayi3,4; Ji, Aiyan3,4; Wang, Hui2; Ding, Chunyong5; Chen, Hao3,4; Xu, Zhiai1
刊名SMALL
出版日期2021-04-01
卷号17期号:13页码:11
ISSN号1613-6810
关键词colorectal cancer combinatory immunotherapy immunogenic cell death prodrug nanoparticles second near‐ infrared fluorescence imaging
DOI10.1002/smll.202007882
通讯作者Wang, Hui(cewangh@imu.edu.cn) ; Ding, Chunyong(chunding@sjtu.edu.cn) ; Xu, Zhiai(zaxu@chem.ecnu.edu.cn)
英文摘要Colorectal cancer (CRC) ranks as the third common and the fourth lethal cancer type worldwide. Immune checkpoint blockade therapy demonstrates great efficacy in a subset of metastatic CRC patients, but precise activation of the antitumor immune response at the tumor site is still challenging. Here a versatile prodrug nanoparticle for second near-infrared (NIR-II) fluorescence imaging-guided combinatory immunotherapy of CRC is reported. The prodrug nanoparticles are constructed with a polymeric oxaliplatin prodrug (PBOXA) and a donor-spacer-acceptor-spacer-donor type small molecular fluorophore TQTCD. The later displays large Stokes shift (>300 nm), fluorescence emission over 1000 nm, and excellent photothermal conversion performance for NIR-II fluorescence imaging-guided photothermal therapy (PTT). The prodrug nanoparticles show seven times higher intratumoral OXA accumulation than free oxaliplatin. TQTCD-based PTT and PBOXA-induced chemotherapy trigger immunogenic cell death of the tumor cells and elicit antitumor immune response in a spatiotemporally controllable manner. Further combination of the prodrug nanoparticle-based PTT/chemotherapy with programmed death ligand 1 blockade significantly promotes intratumoral infiltration of the cytotoxic T lymphocytes and eradicates the CRC tumors. The NIR-II fluorescence imaging-guided immunotherapy may provide a promising approach for CRC treatment.
资助项目National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[22074043] ; International Cooperation Project of Science and Technology Commission of Shanghai Municipality[20430711800] ; Youth Innovation Promotion Association of CAS[2014218] ; China Postdoctoral Science Foundation[2019M661667] ; China Postdoctoral Science Foundation[2020M681429] ; Shanghai Post-Doctoral Excellence Program ; Shanghai Institute of Materia Medica, CAS[FU-SIMM-20182006] ; State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, CAS ; Fudan University[FU-SIMM-20182006]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000627071800001
源URL[http://119.78.100.183/handle/2S10ELR8/295692]  
专题新药研究国家重点实验室
通讯作者Wang, Hui; Ding, Chunyong; Xu, Zhiai
作者单位1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China
2.Inner Mongolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Peoples R China
3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201203, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200241, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Qiurong,Sun, Fang,Li, Tianliang,et al. Engineering Oxaliplatin Prodrug Nanoparticles for Second Near-Infrared Fluorescence Imaging-Guided Immunotherapy of Colorectal Cancer[J]. SMALL,2021,17(13):11.
APA Zhu, Qiurong.,Sun, Fang.,Li, Tianliang.,Zhou, Mengxue.,Ye, Jiayi.,...&Yu, Haijun.(2021).Engineering Oxaliplatin Prodrug Nanoparticles for Second Near-Infrared Fluorescence Imaging-Guided Immunotherapy of Colorectal Cancer.SMALL,17(13),11.
MLA Zhu, Qiurong,et al."Engineering Oxaliplatin Prodrug Nanoparticles for Second Near-Infrared Fluorescence Imaging-Guided Immunotherapy of Colorectal Cancer".SMALL 17.13(2021):11.

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来源：上海药物研究所

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