Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition
文献类型：期刊论文
| 作者 | Ge, Zhan-Peng2; Fan, Yao-Yue2; Deng, Wen-De1; Zheng, Cheng-Yu2; Li, Ting1; Yue, Jian-Min2
|
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2021-03-10 |
| 页码 | 6 |
| 关键词 | [6+6]-cycloaddition C-19-norditerpenoid dimers natural products semisynthesis Th17 cell differentiation |
| ISSN号 | 1433-7851 |
| DOI | 10.1002/anie.202015332 |
| 通讯作者 | Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Cephalodiones A-D (1-4), the first example of C-19-norditerpenoid dimers, were isolated and fully characterized from a Cephalotaxus plant. These new skeletal natural products shared a unique tricyclo[6.4.1.1(2,7)]tetradeca-3,5,9,11-tetraene-13,14-dione core that was capped in both ends with rigid multicyclic ring systems either C-2-symmetrically or asymmetrically. Compounds 1-4 were proposed to be biosynthetically produced by the [6+6]-cycloaddition of two identical C-19-norditerpenoid troponoids, which was validated by the semisyntheses of dimers 2-4. Moreover, some compounds showed significant inhibition on Th17 cell differentiation. |
| 资助项目 | National Natural Science Foundation of the People's Republic of China[81872758] ; National Natural Science Foundation of the People's Republic of China[21532007] ; National Natural Science Foundation of the People's Republic of China[21772213] ; Medical and Health Science and Technology Innovation Project of CAMS[2019-I2M-5-080] ; Biological Resources Program of CAS[ZSTH-032] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000627043400001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295788]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yue, Jian-Min |
| 作者单位 | 1.Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macau, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, Zhan-Peng,Fan, Yao-Yue,Deng, Wen-De,et al. Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021:6. |
| APA | Ge, Zhan-Peng,Fan, Yao-Yue,Deng, Wen-De,Zheng, Cheng-Yu,Li, Ting,&Yue, Jian-Min.(2021).Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6. |
| MLA | Ge, Zhan-Peng,et al."Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021):6. |
入库方式： OAI收割
来源：上海药物研究所
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