Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy
文献类型：期刊论文
| 作者 | Wang, Hong2,3,4; Li, Jie2,3,4; Wang, Zhiwan2,3,4; Wang, Yuqi2,3; Xu, Xiaoxuan2,3,4; Gong, Xiang2,3,4; Wang, Jiaoying2,3; Zhang, Zhiwen1,2,3,4 ; Li, Yaping2,3,4
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| 刊名 | BIOMATERIALS
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| 出版日期 | 2021-02-01 |
| 卷号 | 269页码:15 |
| 关键词 | Melittin Gemcitabine Photodynamic therapy Nanoparticle Immunosuppression |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2020.120609 |
| 通讯作者 | Zhang, Zhiwen(zwzhang0125@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn) |
| 英文摘要 | The robust immunosuppressive microenvironment in tumor represents a key challenge of cancer treatment, and their modulations by versatile therapeutic agents are critically hampered by the limited intratumoral delivery. Herein, we report a bioinspired tumor-responsive theranostic nanovehicle (BTN) with striking tumor-penetrating capability to relieve the profound immunosuppression in tumor for effective cancer therapy. BTN is designed by loading tumor-activated melittin pro-peptide, theranostic photochlor and reactive oxygen species (ROS)responsive prodrug of chemo-immunomodulator gemcitabine into a bioinspired lipoprotein-based nanovehicle, which display prominent tumor accumulation and flexible intratumoral permeation. Notably, the BTN-mediated combinational treatment caused drastic elimination of multiple immunosuppressive cells and remarkable infiltration of cytotoxic lymphocytes in tumor, thereby essentially relieving the tumor immunosuppression and strikingly depressing the tumor growth. Therefore, this design provides an encouraging delivery nanoplatform with distinguished immunosuppression-relieving capacity for effective cancer therapy. |
| 资助项目 | National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FUSIMM20182005] |
| WOS研究方向 | Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000617942500001 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295802]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Zhiwen; Li, Yaping |
| 作者单位 | 1.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hong,Li, Jie,Wang, Zhiwan,et al. Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy[J]. BIOMATERIALS,2021,269:15. |
| APA | Wang, Hong.,Li, Jie.,Wang, Zhiwan.,Wang, Yuqi.,Xu, Xiaoxuan.,...&Li, Yaping.(2021).Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy.BIOMATERIALS,269,15. |
| MLA | Wang, Hong,et al."Tumor-permeated bioinspired theranostic nanovehicle remodels tumor immunosuppression for cancer therapy".BIOMATERIALS 269(2021):15. |
入库方式： OAI收割
来源：上海药物研究所
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