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RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19

文献类型：期刊论文

作者Jiang, Yi1,2; Yin, Wanchao2; Xu, H. Eric1,2,3
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
出版日期2021-01-29
卷号538页码:47-53
关键词COVID-19 SARS-CoV-2 RNA-dependent RNA polymerase Structure RNA recognition Remdesivir
ISSN号0006-291X
DOI10.1016/j.bbrc.2020.08.116
通讯作者Jiang, Yi(yijiang@simm.ac.cn) ; Xu, H. Eric(eric.xu@simm.ac.cn)
英文摘要Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARSCoV-2) has rapidly become a global pandemic. Although great efforts have been made to develop effective therapeutic interventions, only the nucleotide analog remdesivir was approved for emergency use against COVID-19. Remdesivir targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA replication and a promising drug target for COVID-19. Recently, several structures of RdRp in complex with substrate RNA and remdesivir were reported, providing insights into the mechanisms of RNA recognition by RdRp. These structures also reveal the mechanism of RdRp inhibition by nucleotide inhibitors and offer a molecular template for the development of RdRp-targeting drugs. This review discusses the recognition mechanism of RNA and nucleotide inhibitor by RdRp, and its implication in drug discovery. (c) 2020 Elsevier Inc. All rights reserved.
资助项目National Key R&D Programs of China[(501100012166%20:) 2018YFA0507002] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02] ; CAS Strategic Priority Research Program[XDB08020303] ; National Natural Science Foundation of China[31770796] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program[2018ZX09711002]
WOS研究方向Biochemistry & Molecular Biology ; Biophysics
语种英语
WOS记录号WOS:000621177900007
出版者ACADEMIC PRESS INC ELSEVIER SCIENCE
源URL[http://119.78.100.183/handle/2S10ELR8/295806]  
专题中国科学院上海药物研究所
通讯作者Jiang, Yi; Xu, H. Eric
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式
GB/T 7714		 Jiang, Yi,Yin, Wanchao,Xu, H. Eric. RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2021,538:47-53.
APA Jiang, Yi,Yin, Wanchao,&Xu, H. Eric.(2021).RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,538,47-53.
MLA Jiang, Yi,et al."RNA-dependent RNA polymerase: Structure, mechanism, and drug discovery for COVID-19".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 538(2021):47-53.

入库方式： OAI收割

来源：上海药物研究所

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