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W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319

文献类型：期刊论文

作者Zhong, Li2,3; Liu, Qing2; Liu, Qiaofeng1; Zhang, Shikai4; Cao, Yongbing4; Yang, Dehua2; Wang, Ming-Wei1,2,3
刊名CHEMICAL BIOLOGY & DRUG DESIGN
出版日期2021-02-16
页码11
关键词chromatin immunoprecipitation diabetes transcription TXNIP W2476
ISSN号1747-0277
DOI10.1111/cbdd.13828
通讯作者Yang, Dehua(dhyang@simm.ac.cn) ; Wang, Ming-Wei(mwwang@simm.ac.cn)
英文摘要Thioredoxin-interacting protein (TXNIP) overexpression is implicated in the pathogenesis of type 2 diabetes. Previous studies have shown that a small molecule compound (W2476) was able to improve beta-cell dysfunction and exert therapeutic effects in diabetic mice via repression of TXNIP signaling pathway. The impact of W2476 on TXNIP transcription was thus investigated using the chromatin immunoprecipitation method. It was found that W2476 promotes competitive binding of forkhead box O1 transcription factor (FOXO1) to the carbohydrate response element (ChoRE) sequence associated with ChoRE-binding protein (ChREBP)/Mlx interacting protein-like(Mlx) complexes. This interaction hinders the attachment of histone acetyltransferase p300 and reduces histone H4 acetylation on the TXNIP promoter, leading to decreasing TXNIP transcription.
资助项目National Natural Science Foundation of China[81872915] ; National Natural Science Foundation of China[81973373] ; National Natural Science Foundation of China[81773792] ; National Science & Technology Major Project[2018ZX09735-001] ; National Science & Technology Major Project[2018ZX09711002-002-005] ; National Science & Technology Major Project[2018ZX09711002-002-011] ; National Key R&D Program of China[2018YFA0507000] ; Novo Nordisk-CAS Research Fund[NNCAS-2017-1-CC]
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000618522700001
出版者WILEY
源URL[http://119.78.100.183/handle/2S10ELR8/295812]  
专题中国科学院上海药物研究所
通讯作者Yang, Dehua; Wang, Ming-Wei
作者单位1.Fudan Univ, Sch Pharm, Shanghai, Peoples R China
2.Chinese Acad Sci, Natl Ctr Drug Screening, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.Shanghai Univ Tradit Chinese Med, Shanghai TCM Integrated Hosp, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhong, Li,Liu, Qing,Liu, Qiaofeng,et al. W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319[J]. CHEMICAL BIOLOGY & DRUG DESIGN,2021:11.
APA Zhong, Li.,Liu, Qing.,Liu, Qiaofeng.,Zhang, Shikai.,Cao, Yongbing.,...&Wang, Ming-Wei.(2021).W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319.CHEMICAL BIOLOGY & DRUG DESIGN,11.
MLA Zhong, Li,et al."W2476 represses TXNIP transcription via dephosphorylation of FOXO1 at Ser319".CHEMICAL BIOLOGY & DRUG DESIGN (2021):11.

入库方式： OAI收割

来源：上海药物研究所

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