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Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution

文献类型：期刊论文

作者Sun, Xian3,4,5; Zhang, Xiaochuan6,7; Ren, Xiaohong4; Sun, Hongyu4; Wu, Li4; Wang, Caifen4; Ye, Xiaohui1,8; York, Peter9; Gao, Zhaobing7; Jiang, Hualiang1,6,7,8
刊名ADVANCED SCIENCE
出版日期2021-02-08
页码14
关键词dry powder inhalation fluorescence‐ micro optical sectioning tomography inhaled materials pulmonary drug delivery three‐ dimensional rendering
DOI10.1002/advs.202003941
通讯作者Jiang, Hualiang(hljiang@simm.ac.cn) ; Zhang, Jiwen(jwzhang@simm.ac.cn) ; Yin, Xianzhen(xzyin@simm.ac.cn)
英文摘要The effective pulmonary deposition of inhaled particulate carriers loaded with drugs is a prerequisite for therapeutic effects of drug delivery via inhalation route. Revealing the sophisticated lung scaffold and intrapulmonary distribution of particles at three-dimensional (3D), in-situ, and single-particle level remains a fundamental and critical challenge for dry powder inhalation in pre-clinical research. Here, taking advantage of the micro optical sectioning tomography system, the high-precision cross-scale visualization of entire lung anatomy is obtained. Then, co-localized lung-wide datasets of both cyto-architectures and fluorescent particles are collected at full scale with the resolution down to individual particles. The precise spatial distribution pattern reveals the region-specific distribution and structure-associated deposition of the inhalable particles in lungs, which is undetected by previous methods. Overall, this research delivers comprehensive and high-resolution 3D detection of pulmonary drug delivery vectors and provides a novel strategy to evaluate materials distribution for drug delivery.
WOS关键词PULMONARY DRUG-DELIVERY ; CELLS ; ATLAS ; MICE
资助项目Research Foundation of the Shanghai Institute of Materia Medica[CASIMM0120182001] ; National Science and Technology Major Project[2018ZX09721002-009] ; National Science and Technology Major Project[2017ZX09101001-006] ; National Key R&D Program of China[2020YFE0201700] ; Youth Innovation Promotion Association CAS[2018323] ; National Natural Science Foundation of China[81803446]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
出版者WILEY
WOS记录号WOS:000615815600001
源URL[http://119.78.100.183/handle/2S10ELR8/295881]  
专题中国科学院上海药物研究所
通讯作者Jiang, Hualiang; Zhang, Jiwen; Yin, Xianzhen
作者单位1.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai Inst Adv Immunochem Studies, Shanghai 200031, Peoples R China
2.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Beijing 100050, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr MOST & Image Fus Anal, Shanghai 201210, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201210, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
7.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
8.Univ Sci & Technol China, Sch Informat Sci & Technol, Hefei 230027, Peoples R China
9.Univ Bradford, Sch Pharm, Bradford BD7 1DP, W Yorkshire, England
推荐引用方式
GB/T 7714		 Sun, Xian,Zhang, Xiaochuan,Ren, Xiaohong,et al. Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution[J]. ADVANCED SCIENCE,2021:14.
APA Sun, Xian.,Zhang, Xiaochuan.,Ren, Xiaohong.,Sun, Hongyu.,Wu, Li.,...&Yin, Xianzhen.(2021).Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution.ADVANCED SCIENCE,14.
MLA Sun, Xian,et al."Multiscale Co-reconstruction of Lung Architectures and Inhalable Materials Spatial Distribution".ADVANCED SCIENCE (2021):14.

入库方式： OAI收割

来源：上海药物研究所

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