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Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities

文献类型：期刊论文

作者Yin, Fang-Zhou1,3,4; Huan, Xia-Juan4; Mudianta, I. Wayan2; Miao, Ze-Hong4; Wang, Hong1,3; Guo, Yue-Wei1,3,4; Li, Xu-Wen4
刊名CHINESE JOURNAL OF CHEMISTRY
出版日期2021-03-01
卷号39期号:3页码:640-646
关键词Soft coral Lobophytum crassum Cembranoids Anti‐ tumoral activity Stereochemistry
ISSN号1001-604X
DOI10.1002/cjoc.202000539
通讯作者Wang, Hong(hongw@zjut.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要Main observation and conclusion Four new cembranoids, 6-oxo-cembrene-A (1), lobocrassins G-H (2-3), and 14-epi-lobophytolide B (4), along with eight known related compounds (5-12), were isolated from the South China Sea soft coral Lobophytum crassum. Their structures were established by extensive spectroscopic analysis and by comparison of the spectral data with those reported in the literatures. The absolute stereochemistry of 14-epi-lobophytolide B (4) was established by time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculations, whereas that of three known metabolites (6, 11 and 12) was also determined, for the first time, by using modified Mosher's method and/or X-ray diffraction analyses. In bioassay, the cembranoids 6, 7 and 12 showed significant anti-tumoral activity against A549, HT-29, SNU-398 and Capan-1 tumor cell lines with IC50 values ranging from 1.5 to 7.4 mu mol/L. A preliminary structure-activity relationship was also discussed.
资助项目National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[81520108028] ; National Natural Science Foundation of China[21672230] ; National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; National 111 Project[D17012] ; Shanghai Rising-Star Program[20QA1411100] ; SA-SIBS Scholarship Program
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000615941100001
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/295884]  
专题新药研究国家重点实验室
通讯作者Wang, Hong; Guo, Yue-Wei; Li, Xu-Wen
作者单位1.Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China
2.Univ Pendidikan Ganesha, Dept Chem, Bali 81116, Indonesia
3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yin, Fang-Zhou,Huan, Xia-Juan,Mudianta, I. Wayan,et al. Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities[J]. CHINESE JOURNAL OF CHEMISTRY,2021,39(3):640-646.
APA Yin, Fang-Zhou.,Huan, Xia-Juan.,Mudianta, I. Wayan.,Miao, Ze-Hong.,Wang, Hong.,...&Li, Xu-Wen.(2021).Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities.CHINESE JOURNAL OF CHEMISTRY,39(3),640-646.
MLA Yin, Fang-Zhou,et al."Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti-tumoral Activities".CHINESE JOURNAL OF CHEMISTRY 39.3(2021):640-646.

入库方式： OAI收割

来源：上海药物研究所

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