Stabilizing photo-sensitive colchicine through rebalancing electron distribution of the reactive tropolone ring
文献类型：期刊论文
| 作者 | Ma, Xiaoyu1,2; Zhu, Bingqing2; Yang, Zeen1,2; Jiang, Yuhang1,2; Mei, Xuefeng1,2
|
| 刊名 | CRYSTENGCOMM
 |
| 出版日期 | 2021-01-07 |
| 卷号 | 23期号:1页码:30-34 |
| ISSN号 | 1466-8033 |
| DOI | 10.1039/d0ce01551b |
| 通讯作者 | Mei, Xuefeng(xuefengmei@simm.ac.cn) |
| 英文摘要 | Colchicine is light-sensitive and undergoes electrocyclic reaction upon exposure to light. In this study, the photostability of colchicine was found to be significantly improved via rebalancing the electron density of the tropolone ring system after solid form changes. This work may provide a new approach for resolving photo-sensitive challenges during drug development. |
| WOS关键词 | NBO |
| 资助项目 | National Science and Technology Major Projects[2017ZX09101001] ; Natural Science Foundation of Shanghai[18ZR1447900] ; Youth Innovation Promotion Association CAS[2016257] |
| WOS研究方向 | Chemistry ; Crystallography |
| 语种 | 英语 |
| WOS记录号 | WOS:000607726200003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295898]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Mei, Xuefeng |
| 作者单位 | 1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ma, Xiaoyu,Zhu, Bingqing,Yang, Zeen,et al. Stabilizing photo-sensitive colchicine through rebalancing electron distribution of the reactive tropolone ring[J]. CRYSTENGCOMM,2021,23(1):30-34. |
| APA | Ma, Xiaoyu,Zhu, Bingqing,Yang, Zeen,Jiang, Yuhang,&Mei, Xuefeng.(2021).Stabilizing photo-sensitive colchicine through rebalancing electron distribution of the reactive tropolone ring.CRYSTENGCOMM,23(1),30-34. |
| MLA | Ma, Xiaoyu,et al."Stabilizing photo-sensitive colchicine through rebalancing electron distribution of the reactive tropolone ring".CRYSTENGCOMM 23.1(2021):30-34. |
入库方式： OAI收割
来源：上海药物研究所
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