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Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker-Gawl. as a case study

文献类型：期刊论文

作者Jin, Xu1,2; Zhang, Jianqing1; Li, Yun1; Wu, Wenyong1,2; Zhang, Hang1,2; Yao, Changliang1; Wei, Wenlong1; Yao, Shuai1; Huang, Yong1; Qu, Hua1
刊名JOURNAL OF SEPARATION SCIENCE
出版日期2021-02-10
页码12
ISSN号1615-9306
关键词authentication multicriteria decision making nontargeted metabolomics quality markers traditional Chinese medicine
DOI10.1002/jssc.202000655
通讯作者Guo, De-an(daguo@simm.ac.cn)
英文摘要A key segment in medicinal plant authentication is the establishment of quality markers that embody the intrinsic metabolites difference independent of instruments and experiment conditions. A strategy integrating nontargeted metabolomics and multicriteria decision-making model for robust quality markers discovery is presented and applied to authenticate Ophiopogon japonicus (L. f.) Ker-Gawl. First, an ultra-performance liquid chromatography/quadrupole time-of-flight MSE approach was established for global metabolites profiling and identification. Second, multivariate statistical analysis was performed to explore potential quality markers of different origins of ophiopogonis radix. Third, potential quality markers were ordered and filtered by multicriteria decision-making model to infer robust quality markers and further validated in different instruments and experiment conditions by validation model. Fourth, the validation model using the robust quality markers managed to discriminate the origins of ophiopogonis radix samples procured from the herbal markets. Consequently, two robust quality markers, cixi-ophiopogon B and ophiopogonin D, were discovered and further validated on different instruments and experiment conditions. This integrated strategy provided a practical solution for reliable and convenient authentication of geo-authentic herb.
资助项目National Key R&D Program of China[2019YFC1711000] ; National Key R&D Program of China[2018YFC1707900] ; National Natural Science Foundation of China[81530095]
WOS研究方向Chemistry
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000616480600001
源URL[http://119.78.100.183/handle/2S10ELR8/295901]  
专题中国科学院上海药物研究所
通讯作者Guo, De-an
作者单位1.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Natl Engn Lab TCM Standardizat Technol, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Jin, Xu,Zhang, Jianqing,Li, Yun,et al. Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker-Gawl. as a case study[J]. JOURNAL OF SEPARATION SCIENCE,2021:12.
APA Jin, Xu.,Zhang, Jianqing.,Li, Yun.,Wu, Wenyong.,Zhang, Hang.,...&Guo, De-an.(2021).Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker-Gawl. as a case study.JOURNAL OF SEPARATION SCIENCE,12.
MLA Jin, Xu,et al."Nontargeted metabolomic analysis and multiple criteria decision-making method induced robust quality markers screening for the authentication of herbal medicines from different origins by taking Ophiopogon japonicus (L. f.) Ker-Gawl. as a case study".JOURNAL OF SEPARATION SCIENCE (2021):12.

入库方式： OAI收割

来源：上海药物研究所

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