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Different Solid Forms of Vitamin K-3 and Their Effect on the Chemical Stability

文献类型：期刊论文

作者Yang, Zeen1,2; Zhu, Bingqing1; Jiang, Yuhang1,2; Zhang, Zaiyong1; Dai, Wenjuan1; Mei, Xuefeng1,2
刊名CRYSTAL GROWTH & DESIGN
出版日期2021-01-06
卷号21期号:1页码:528-535
ISSN号1528-7483
DOI10.1021/acs.cgd.0c01324
通讯作者Mei, Xuefeng(xuefengmei@simm.ac.cn)
英文摘要MSB, the commercially available form of vitamin K-3, has been widely applied in medicine, the nutrition industry, and livestock feed for decades. However, undesired degradation in an alkaline environment significantly decreases its efficacy and limits its application. Herein, polymorphism screening was performed on MSB to obtain solid forms with improved chemical stability. Two new solid forms were discovered, including form A and HB. Their crystal structures were elucidated by single crystal X-ray diffraction, and these forms were adequately characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and dynamic vapor sorption. The transformation relationships between these solid forms were fully discussed. Single-crystal-to-single-crystal transformation behavior was also detected by X-ray diffraction and hot-stage microscopy. The chemical stability in an alkaline environment of the newly discovered forms was investigated and compared with that of the marketed form. It was found that form A significantly alleviates the degradation of MSB. This gratifying chemical stability may be attributed to its compact packing pattern and the molecular conformation advantage.
WOS关键词MOLECULAR COMPASSES ; CRYSTAL-STRUCTURES ; K DEFICIENCY ; GYROSCOPES ; DYNAMICS ; POLYMORPHS ; RITONAVIR ; ROTOR
资助项目Major National Science and Technology[2017ZX091-01001] ; Natural Science Foundation of Shanghai[18ZR1447900]
WOS研究方向Chemistry ; Crystallography ; Materials Science
语种英语
WOS记录号WOS:000607623900053
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/295911]  
专题中国科学院上海药物研究所
通讯作者Mei, Xuefeng
作者单位1.Chinese Acad Sci, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Zeen,Zhu, Bingqing,Jiang, Yuhang,et al. Different Solid Forms of Vitamin K-3 and Their Effect on the Chemical Stability[J]. CRYSTAL GROWTH & DESIGN,2021,21(1):528-535.
APA Yang, Zeen,Zhu, Bingqing,Jiang, Yuhang,Zhang, Zaiyong,Dai, Wenjuan,&Mei, Xuefeng.(2021).Different Solid Forms of Vitamin K-3 and Their Effect on the Chemical Stability.CRYSTAL GROWTH & DESIGN,21(1),528-535.
MLA Yang, Zeen,et al."Different Solid Forms of Vitamin K-3 and Their Effect on the Chemical Stability".CRYSTAL GROWTH & DESIGN 21.1(2021):528-535.

入库方式： OAI收割

来源：上海药物研究所

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