Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B
文献类型：期刊论文
| 作者 | Mu, Xu-Yang2; Wang, Zhi-Jia2; Feng, Bo2; Xu, Lei1; Gao, Li-Xin1; Satheeshkumar, Rajendran2,3; Li, Jia1 ; Zhou, Yu-Bo1; Wang, Wen-Long2
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2021-01-27 |
| 卷号 | 11期号:6页码:3216-3220 |
| DOI | 10.1039/d0ra09247a |
| 通讯作者 | Zhou, Yu-Bo(ybzhou@simm.ac.cn) ; Wang, Wen-Long(wwenlong2011@163.com) |
| 英文摘要 | A series of 2-ethoxycarbonylthieno[2,3-b]quinolines were synthesized in the bio-derived "green" solvent gamma-valerolactone (GVL) and evaluated for their inhibitory activities against PTP1B, the representative compound 6a displayed an IC50 value of 8.04 +/- 0.71 mu M with 4.34-fold preference over TCPTP. These results provided novel lead compounds for the design of inhibitors of PTP1B as well as other PTPs. |
| WOS关键词 | SUSTAINABLE PRACTICES ; GREEN CHEMISTRY ; DERIVATIVES ; CHLORIDES ; AMIDES ; PTP1B |
| 资助项目 | National Natural Science Foundation of China[21772068] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002] ; Natural Science Foundation of Jiangsu Province[BK20190608] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000611287900003 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/295963]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhou, Yu-Bo; Wang, Wen-Long |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Jiangnan Univ, Sch Pharmaceut Sci, Wuxi 214122, Jiangsu, Peoples R China 3.Pontificia Univ Catolica Chile, Fac Quim & Farm, Dept Quim Organ, Santiago 702843, Chile |
| 推荐引用方式 GB/T 7714 | Mu, Xu-Yang,Wang, Zhi-Jia,Feng, Bo,et al. Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B[J]. RSC ADVANCES,2021,11(6):3216-3220. |
| APA | Mu, Xu-Yang.,Wang, Zhi-Jia.,Feng, Bo.,Xu, Lei.,Gao, Li-Xin.,...&Wang, Wen-Long.(2021).Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B.RSC ADVANCES,11(6),3216-3220. |
| MLA | Mu, Xu-Yang,et al."Synthesis of 2-ethoxycarbonylthieno[2,3-b]quinolines in biomass-derived solvent gamma-valerolactone and their biological evaluation against protein tyrosine phosphatase 1B".RSC ADVANCES 11.6(2021):3216-3220. |
入库方式： OAI收割
来源：上海药物研究所
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