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Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy

文献类型：期刊论文

作者Yan, Wenlu1,2,3,4; Lang, Tianqun2,3,4; Qi, Xianrong1; Li, Yaping2,3,4
刊名CURRENT OPINION IN BIOTECHNOLOGY
出版日期2020-12-01
卷号66页码:36-43
ISSN号0958-1669
DOI10.1016/j.copbio.2020.06.007
通讯作者Li, Yaping(ypli@simm.ac.cn)
英文摘要Many anti-cancer therapies can induce or enhance the immunogenic cell death (ICD), a process that releases damage-associated molecular patterns (DAMPs) to prime antigen processing and presentation necessary for successful cancer immunotherapy. However, the clinical potential of these therapies, especially the chemotherapy, is limited by serious systemic side effects, because of their non-specific accumulation out of the tumors. Nanosized drug delivery systems (NDDSs) can improve the specificity of anti-cancer therapies, which enhance ICD in the tumor while alleviating toxicities. In this review, we summarize recent progress of ICD-inducing NDDSs with a focus on their enhanced safety and efficacy for cancer immunotherapy.
WOS关键词IMMUNE CHECKPOINT BLOCKADE ; NANOPARTICLES ; RADIOTHERAPY ; RESISTANCE ; INDUCERS
资助项目National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[81630052] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Natural Science Foundation of Shanghai[19ZR1479900] ; Key Scientific Research Program of CAS[QYZDJSSW-SMC020]
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:000601001000006
出版者CURRENT BIOLOGY LTD
源URL[http://119.78.100.183/handle/2S10ELR8/296047]  
专题新药研究国家重点实验室
通讯作者Li, Yaping
作者单位1.Peking Univ, Sch Pharmaceut Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
4.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yan, Wenlu,Lang, Tianqun,Qi, Xianrong,et al. Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy[J]. CURRENT OPINION IN BIOTECHNOLOGY,2020,66:36-43.
APA Yan, Wenlu,Lang, Tianqun,Qi, Xianrong,&Li, Yaping.(2020).Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy.CURRENT OPINION IN BIOTECHNOLOGY,66,36-43.
MLA Yan, Wenlu,et al."Engineering immunogenic cell death with nanosized drug delivery systems improving cancer immunotherapy".CURRENT OPINION IN BIOTECHNOLOGY 66(2020):36-43.

入库方式： OAI收割

来源：上海药物研究所

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