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The milestone of genetic screening: Mammalian haploid cells

文献类型：期刊论文

作者Sun, Shengyi1,3; Zhao, Yiding1,3; Shuai, Ling1,2,3,4
刊名COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
出版日期2020
卷号18页码:2471-2479
关键词Mammalian haploid cells Self-diploidization Genetic screening Imprinted genes
ISSN号2001-0370
DOI10.1016/j.csbj.2020.09.006
通讯作者Shuai, Ling(lshuai@nankai.edu.cn)
英文摘要Mammalian haploid cells provide insights into multiple genetics approaches as have been proved by advances in homozygous phenotypes and function as gametes. Recent achievements make ploidy of mammalian haploid cells stable and improve the developmental efficiency of embryos derived from mammalian haploid cells intracytoplasmic microinjection, which promise great potentials for using mammalian haploid cells in forward and reverse genetic screening. In this review, we introduce breakthroughs of mammalian haploid cells involving in mechanisms of self-diploidization, forward genetics for various targeting genes and imprinted genes related development. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
WOS关键词EMBRYONIC STEM-CELLS ; MICROSURGICAL REMOVAL ; GENOMIC DNA ; GENERATION ; DERIVATION ; MICE ; ESTABLISHMENT ; DIPLOIDIZATION ; TRANSITION ; FREQUENCY
资助项目National Key Research and Development Program of China[2018YFC1004101] ; National Key Research and Development Program of China[2019YFA0109901] ; Fundamental Research Funds for the Central Universities of Nankai University[63191731] ; National Natural Science Foundation of China[31671538] ; National Natural Science Foundation of China[31872841] ; Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine, Ferring Pharmaceuticals and Chinese Academy of Sciences[FIRMD181102] ; Open Fund of Tianjin Central Hospital of Gynecology Obstetrics/Tianjin Key Laboratory of human development and reproductive regulation[2019XHY08]
WOS研究方向Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
语种英语
WOS记录号WOS:000607355500005
出版者ELSEVIER
源URL[http://119.78.100.183/handle/2S10ELR8/296079]  
专题中国科学院上海药物研究所
通讯作者Shuai, Ling
作者单位1.Nankai Univ, Coll Pharm, Tianjin 300350, Peoples R China
2.Tianjin Cent Hosp Gynecol Obstet, Tianjin Key Lab Human Dev & Reprod Regulat, Tianjin 300052, Peoples R China
3.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, Tate Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Sun, Shengyi,Zhao, Yiding,Shuai, Ling. The milestone of genetic screening: Mammalian haploid cells[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2020,18:2471-2479.
APA Sun, Shengyi,Zhao, Yiding,&Shuai, Ling.(2020).The milestone of genetic screening: Mammalian haploid cells.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,18,2471-2479.
MLA Sun, Shengyi,et al."The milestone of genetic screening: Mammalian haploid cells".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 18(2020):2471-2479.

入库方式： OAI收割

来源：上海药物研究所

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