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Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity

文献类型：期刊论文

作者Ji, Hong-Jian1,2,3; Li, Jia-Yuan2; Wu, Shi-Fei2; Wu, Wen-Yong1; Yao, Chang-Liang2; Yao, Shuai2; Zhang, Jian-Qing2; Guo, De-An1,2
刊名MOLECULES
出版日期2021
卷号26期号:1页码:11
关键词Aristolochia contorta aristolochic acid cytotoxicity molecular docking
DOI10.3390/molecules26010044
通讯作者Guo, De-An(daguo@simm.ac.cn)
英文摘要Twelve compounds, including two new aristolochic acid analogues with a formyloxy moiety (9-10) and 10 known aristolochic acid derivates (1-8 and 11-12), were obtained from the roots of Aristolochia contorta. Their structures were elucidated using extensive spectroscopic methods. Their cytotoxic activity in human proximal tubular cells HK-2 was evaluated by the MTT method, which has been widely used to assess cell viability. Among these molecules, compounds 3 and 9 were found to be more cytotoxic. Furthermore, molecular modeling was used to evaluate, for the first time, the interactions of compounds 3 and 9 with the target protein organic anionic transporter 1 (OAT1) that plays a key role in mediating aristolochic acid nephropathy. Structure-activity relationships are briefly discussed.
WOS关键词CONSTITUENTS
资助项目Jiangsu Provincial Commission of Health and Family Planning, China[QNRC2016465]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000606223200001
出版者MDPI
源URL[http://119.78.100.183/handle/2S10ELR8/296104]  
专题中国科学院上海药物研究所
通讯作者Guo, De-An
作者单位1.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Xianlin Rd 138, Nanjing 210023, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Nanjing Med Univ, Yancheng Sch Clin Med, Dept Pharm, Yancheng 224001, Peoples R China
推荐引用方式
GB/T 7714		 Ji, Hong-Jian,Li, Jia-Yuan,Wu, Shi-Fei,et al. Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity[J]. MOLECULES,2021,26(1):11.
APA Ji, Hong-Jian.,Li, Jia-Yuan.,Wu, Shi-Fei.,Wu, Wen-Yong.,Yao, Chang-Liang.,...&Guo, De-An.(2021).Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity.MOLECULES,26(1),11.
MLA Ji, Hong-Jian,et al."Two New Aristolochic Acid Analogues from the Roots of Aristolochia contorta with Significant Cytotoxic Activity".MOLECULES 26.1(2021):11.

入库方式： OAI收割

来源：上海药物研究所

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